Anthracimycin B, a Potent Antibiotic against Gram-Positive Bacteria Isolated from Cultures of the Deep-Sea Actinomycete Streptomyces cyaneofuscatus M-169.
Víctor Rodríguez Martín-AragónJesús MartínAida Sarmiento-VizcaínoMercedes de la CruzLuis A GarcíaGloria BlancoFernando ReyesPublished in: Marine drugs (2018)
The potent antimicrobial extract of a culture of the marine derived actinomycete Streptomyces cyaneofuscatus M-169 was fractionated by reversed phase flash chromatography and preparative HPLC to yield the new Gram-positive antibiotic, anthracimycin B (1), together with its congener, anthracimycin (2). The structure of the new compound was established by analysis of its ESI-TOF MS and 1D and 2D NMR spectra, and comparison with data published for anthracimycin and anthracimycin BII-2619 (3). Notably, anthracimycin seemed to be the major and almost unique component of the extract detected by HPLC-UV-MS, making our S. cyanofuscatus strain an excellent candidate for further biosynthetic studies of this potent antibiotic.
Keyphrases
- ms ms
- mass spectrometry
- anti inflammatory
- gram negative
- high performance liquid chromatography
- simultaneous determination
- tandem mass spectrometry
- oxidative stress
- magnetic resonance
- multiple sclerosis
- high resolution
- staphylococcus aureus
- liquid chromatography
- electronic health record
- randomized controlled trial
- machine learning
- multidrug resistant
- high speed
- density functional theory
- deep learning
- molecular dynamics
- clinical evaluation