Cerebellar α6 -subunit-containing GABAA receptors: a novel therapeutic target for disrupted prepulse inhibition in neuropsychiatric disorders.

Lih-Chu ChiouHsin-Jung LeeMargot ErnstWei-Jan HuangJui-Feng ChouHon-Lie ChenAkihiro MouriLiang-Chieh ChenMarco TrevenTakayoshi MamiyaPi-Chuan FanDaniel E KnutsonChris WitzigmannJames M Cook Werner SieghartToshitaka Nabeshima

Published in: British journal of pharmacology (2018)

Positive allosteric modulation of cerebellar α6 GABAA receptors rescued disrupted PPI by attenuating granule cell activity. α6 GABAA receptor-selective PAMs are potential medicines for treating sensorimotor gating deficits in neuropsychiatric disorders. A mechanistic hypothesis is based on evidence for cerebellar contributions to cognitive functioning including sensorimotor gating.

Keyphrases

functional connectivity
resting state
small molecule
single cell
cell therapy
stem cells
bone marrow
binding protein