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Liver Transplantation Outcomes in a U.S. Multicenter Cohort of 789 Patients With Hepatocellular Carcinoma Presenting Beyond Milan Criteria.

Ani A KardashianSander S FlormanBrandy HaydelRichard M RuizGoran B KlintmalmDavid D LeeC Burcin TanerFederico AucejoAmit D TevarAbhinav HumarElizabeth C VernaKarim J HalazunWilliam C ChapmanNeeta VachharajaniMaarouf HoteitMatthew H LevineMindie H NguyenMarc L MelcherAlan N LangnasCarol A CarneyConstance MobleyMark GhobrialBeth AmundsenJames F MarkmannDebra L SudanChristopher M JonesJennifer BerumenAlan W HemmingJohnny C HongJoohyun KimMichael A ZimmermanTrevor L NydamAbbas RanaMichael L KuehtThomas M FishbeinDaniela MarkovicRonald W BusuttilVatche G Agopian
Published in: Hepatology (Baltimore, Md.) (2021)
In LT recipients with HCC presenting beyond MC, successful down-staging is predicted by wait time, alpha-fetoprotein response to LRT, and tumor burden and results in excellent post-LT outcomes, justifying expansion of LT criteria. In LRT-NoDS patients, higher HCC-R compared with NoLRT-NoDS cannot be explained by clinicopathologic differences, suggesting a potentially aggravating role of LRT in patients with poor tumor biology that warrants further investigation.
Keyphrases
  • end stage renal disease
  • newly diagnosed
  • ejection fraction
  • chronic kidney disease
  • case report
  • peritoneal dialysis
  • prognostic factors
  • lymph node
  • type diabetes
  • cross sectional
  • pet ct
  • adipose tissue