Liver Transplantation Outcomes in a U.S. Multicenter Cohort of 789 Patients With Hepatocellular Carcinoma Presenting Beyond Milan Criteria.
Ani A KardashianSander S FlormanBrandy HaydelRichard M RuizGoran B KlintmalmDavid D LeeC Burcin TanerFederico AucejoAmit D TevarAbhinav HumarElizabeth C VernaKarim J HalazunWilliam C ChapmanNeeta VachharajaniMaarouf HoteitMatthew H LevineMindie H NguyenMarc L MelcherAlan N LangnasCarol A CarneyConstance MobleyMark GhobrialBeth AmundsenJames F MarkmannDebra L SudanChristopher M JonesJennifer BerumenAlan W HemmingJohnny C HongJoohyun KimMichael A ZimmermanTrevor L NydamAbbas RanaMichael L KuehtThomas M FishbeinDaniela MarkovicRonald W BusuttilVatche G AgopianPublished in: Hepatology (Baltimore, Md.) (2021)
In LT recipients with HCC presenting beyond MC, successful down-staging is predicted by wait time, alpha-fetoprotein response to LRT, and tumor burden and results in excellent post-LT outcomes, justifying expansion of LT criteria. In LRT-NoDS patients, higher HCC-R compared with NoLRT-NoDS cannot be explained by clinicopathologic differences, suggesting a potentially aggravating role of LRT in patients with poor tumor biology that warrants further investigation.