Phenome-wide association study (PheWAS) of colorectal cancer risk SNP effects on health outcomes in UK Biobank.

Xiaomeng Zhang Xue Li Yazhou HePhilip J LawSusan M FarringtonHarry CampbellIan P M TomlinsonRichard S HoulstonMalcolm G DunlopMaria N Timofeeva Evropi Theodoratou

Published in: British journal of cancer (2021)

We show that benign colorectal neoplasms share genetic aetiology with CRC using PheWAS and TreeWAS methods. Additionally, CRC genetic predisposition is associated with diverticular disease.

Keyphrases

genome wide
copy number
dna methylation
cross sectional
genetic diversity