Neuropathology-Independent Association Between APOE Genotype and Cognitive Decline Rate in the Normal Aging-Early Alzheimer Continuum.

Jing QianYiding ZhangRebecca A Betensky Bradley T Hyman Alberto Serrano-Pozo

Published in: Neurology. Genetics (2023)

ε4 allele is associated with a modest but statistically significant acceleration of the cognitive decline rate even after controlling for its effects on ADNC and comorbid pathologies.

Keyphrases

cognitive decline
mild cognitive impairment
type diabetes
metabolic syndrome
skeletal muscle