Bradley T Hyman (B T Hyman, Bradley Hyman)

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 91

Top Topics

Transcription Factor

Cognitive Decline

Machine Learning

Raman Spectroscopy

Top Venues

Nature communications

Acta neuropathologica communications

This page only lists publications with an associated author ORCID identifier.

Publications

Leonardo D Garma, Lisbeth Harder, Juan M Barba-Reyes, Sergio Marco Salas, Mónica Díez-Salguero, Mats Nilsson, Alberto Serrano-Pozo, Bradley T Hyman, Ana Belén Muñoz-Manchado
Interneuron diversity in the human dorsal striatum. Nature communications 15 (1) (2024)
Leonardo D Garma, Lisbeth Harder, Juan M Barba-Reyes, Sergio Marco Salas, Mónica Díez-Salguero, Mats Nilsson, Alberto Serrano-Pozo, Bradley T Hyman, Ana Belén Muñoz-Manchado
Interneuron diversity in the human dorsal striatum. Nature communications 15 (1) (2024)
Zachary Hoglund, Nancy Ruiz-Uribe, Eric Del Sastre, Benjamin Woost, Joshua Bailey, Bradley T Hyman, Theodore J Zwang, Rachel E Bennett
Brain Vasculature Accumulates Tau and Is Spatially Related to Tau Tangle Pathology in Alzheimer's Disease. bioRxiv : the preprint server for biology (2024)
Rosemary J Jackson, Bradley T Hyman, Alberto Serrano-Pozo
Multifaceted roles of APOE in Alzheimer disease. Nature reviews. Neurology (2024)
Mukesh Kumar, Noé Quittot, Simon Dujardin, Christoph N Schlaffner, Arthur Viode, Anne Wiedmer, Pieter Beerepoot, Joshua E Chun, Calina Glynn, Analiese R Fernandes, Cameron Donahue, Judith A Steen, Bradley T Hyman
Alzheimer proteopathic tau seeds are biochemically a forme fruste of mature paired helical filaments. Brain : a journal of neurology 147 (2) (2024)
Anastasie Mate de Gerando, Anita Khasnavis, Lindsay A Welikovitch, Harshil Bhavsar, Calina Glynn, Noe Quittot, Romain Perbet, Bradley T Hyman
Aqueous extractable nonfibrillar and sarkosyl extractable fibrillar Alzheimer's disease tau seeds have distinct properties. Acta neuropathologica communications 12 (1) (2024)
Jeffery M Vance, Lindsay A Farrer, Yadong Huang, Cruchaga Carlos, Bradley T Hyman, Margaret A Pericak-Vance, Alison M Goate, Michael D Greicius, Anthony J Griswold, Jonathan L Haines, Julia Tcw, Gerard D Schellenberg, Li-Huei Tsai, Joachim Herz, David M Holtzman
Report of the APOE4 National Institute on Aging/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing APOE4 in Carriers is a Therapeutic Goal for Alzheimer's Disease. Annals of neurology 95 (4) (2024)
Mukesh Kumar, Noé Quittot, Simon Dujardin, Christoph N Schlaffner, Arthur Viode, Anne Wiedmer, Pieter Beerepoot, Joshua E Chun, Calina Glynn, Analiese R Fernandes, Cameron Donahue, Judith A Steen, Bradley T Hyman
Alzheimer proteopathic tau seeds are biochemically a forme fruste of mature paired helical filaments. Brain : a journal of neurology (2024)
Harshvardhan Gazula, Henry F J Tregidgo, Benjamin Billot, Yael Balbastre, Jonathan Williams-Ramirez, Rogeny Herisse, Lucas J Deden-Binder, Adria Casamitjana, Erica J Melief, Caitlin S Latimer, Mitchell D Kilgore, Mark Montine, Eleanor Robinson, Emily Blackburn, Michael S Marshall, Theresa R Connors, Derek H Oakley, Matthew P Frosch, Sean I Young, Koen Van Leemput, Adrian V Dalca, Bruce Fischl, Christine L MacDonald, C Dirk Keene, Bradley T Hyman, Juan Eugenio Iglesias
Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology. eLife 12 (2024)
Leonardo D Garma, Lisbeth Harder, Juan M Barba-Reyes, Sergio Marco Salas, Mónica Díez-Salguero, Mats Nilsson, Alberto Serrano-Pozo, Bradley T Hyman, Ana Belén Muñoz-Manchado
Interneuron diversity in the human dorsal striatum. Nature communications 15 (1) (2024)
Rosemary J Jackson, Alexandra Melloni, Dustin P Fykstra, Alberto Serrano-Pozo, Leslie Shinobu, Bradley T Hyman
Astrocyte tau deposition in progressive supranuclear palsy is associated with dysregulation of MAPT transcription. Acta neuropathologica communications 12 (1) (2024)
Rosemary J Jackson, Bradley T Hyman, Alberto Serrano-Pozo
Multifaceted roles of APOE in Alzheimer disease. Nature reviews. Neurology 20 (8) (2024)
Rosemary J Jackson, Alexandra Melloni, Dustin P Fykstra, Alberto Serrano-Pozo, Leslie Shinobu, Bradley T Hyman
Astrocyte tau deposition in progressive supranuclear palsy is associated with dysregulation of MAPT transcription. Acta neuropathologica communications 12 (1) (2024)
Jeffery M Vance, Lindsay A Farrer, Yadong Huang, Cruchaga Carlos, Bradley T Hyman, Margaret A Pericak-Vance, Alison M Goate, Michael D Greicius, Anthony J Griswold, Jonathan L Haines, Julia Tcw, Gerard D Schellenberg, Li-Huei Tsai, Joachim Herz, David M Holtzman
Report of the APOE4 National Institute on Aging/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing APOE4 in Carriers is a Therapeutic Goal for Alzheimer's Disease. Annals of neurology (2024)
Leonardo D Garma, Lisbeth Harder, Juan M Barba-Reyes, Sergio Marco Salas, Mónica Díez-Salguero, Mats Nilsson, Alberto Serrano-Pozo, Bradley T Hyman, Ana Belén Muñoz-Manchado
Interneuron diversity in the human dorsal striatum. Nature communications 15 (1) (2024)
Harshvardhan Gazula, Henry F J Tregidgo, Benjamin Billot, Yael Balbastre, Jonathan Williams-Ramirez, Rogeny Herisse, Lucas J Deden-Binder, Adria Casamitjana, Erica J Melief, Caitlin S Latimer, Mitchell D Kilgore, Mark Montine, Eleanor Robinson, Emily Blackburn, Michael S Marshall, Theresa R Connors, Derek H Oakley, Matthew P Frosch, Sean I Young, Koen Van Leemput, Adrian V Dalca, Bruce Fischl, Christine L MacDonald, C Dirk Keene, Bradley T Hyman, Juan Eugenio Iglesias
Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology. eLife 12 (2024)
Harshvardhan Gazula, Henry F J Tregidgo, Benjamin Billot, Yael Balbastre, Jonathan Williams-Ramirez, Rogeny Herisse, Lucas J Deden-Binder, Adria Casamitjana, Erica J Melief, Caitlin S Latimer, Mitchell D Kilgore, Mark Montine, Eleanor Robinson, Emily Blackburn, Michael S Marshall, Theresa R Connors, Derek H Oakley, Matthew P Frosch, Sean I Young, Koen Van Leemput, Adrian V Dalca, Bruce Fischl, Christine L MacDonald, C Dirk Keene, Bradley T Hyman, Juan Eugenio Iglesias
Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology. eLife 12 (2024)
Rosemary J Jackson, Alexandra Melloni, Dustin P Fykstra, Alberto Serrano-Pozo, Leslie Shinobu, Bradley T Hyman
Astrocyte tau deposition in progressive supranuclear palsy is associated with dysregulation of MAPT transcription. Acta neuropathologica communications 12 (1) (2024)
Mukesh Kumar, Noé Quittot, Simon Dujardin, Christoph N Schlaffner, Arthur Viode, Anne Wiedmer, Pieter Beerepoot, Joshua E Chun, Calina Glynn, Analiese R Fernandes, Cameron Donahue, Judith A Steen, Bradley T Hyman
Alzheimer proteopathic tau seeds are biochemically a forme fruste of mature paired helical filaments. Brain : a journal of neurology 147 (2) (2024)
Dah-Eun Chloe Chung, Xue Deng, Hari Krishna Yalamanchili, Jean-Pierre Revelli, Alexander L Han, Bakhos Tadros, Ronald Richman, Michelle Dias, Fatemeh Alavi Naini, Steven Boeynaems, Bradley T Hyman, Huda Yaya Zoghbi
The big tau splice isoform resists Alzheimer's-related pathological changes. bioRxiv : the preprint server for biology (2024)
Zachary Hoglund, Nancy Ruiz-Uribe, Eric Del Sastre, Benjamin Woost, Joshua Bailey, Bradley T Hyman, Theodore J Zwang, Rachel E Bennett
Brain Vasculature Accumulates Tau and Is Spatially Related to Tau Tangle Pathology in Alzheimer's Disease. bioRxiv : the preprint server for biology (2024)
Mukesh Kumar, Noé Quittot, Simon Dujardin, Christoph N Schlaffner, Arthur Viode, Anne Wiedmer, Pieter Beerepoot, Joshua E Chun, Calina Glynn, Analiese R Fernandes, Cameron Donahue, Judith A Steen, Bradley T Hyman
Alzheimer proteopathic tau seeds are biochemically a forme fruste of mature paired helical filaments. Brain : a journal of neurology 147 (2) (2024)
Zachary Hoglund, Nancy Ruiz-Uribe, Eric Del Sastre, Benjamin Woost, Joshua Bailey, Bradley T Hyman, Theodore J Zwang, Rachel E Bennett
Brain Vasculature Accumulates Tau and Is Spatially Related to Tau Tangle Pathology in Alzheimer's Disease. bioRxiv : the preprint server for biology (2024)
Leonardo D Garma, Lisbeth Harder, Juan M Barba-Reyes, Sergio Marco Salas, Mónica Díez-Salguero, Mats Nilsson, Alberto Serrano-Pozo, Bradley T Hyman, Ana Belén Muñoz-Manchado
Interneuron diversity in the human dorsal striatum. Nature communications 15 (1) (2024)
Jeffery M Vance, Lindsay A Farrer, Yadong Huang, Cruchaga Carlos, Bradley T Hyman, Margaret A Pericak-Vance, Alison M Goate, Michael D Greicius, Anthony J Griswold, Jonathan L Haines, Julia Tcw, Gerard D Schellenberg, Li-Huei Tsai, Joachim Herz, David M Holtzman
Report of the APOE4 National Institute on Aging/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing APOE4 in Carriers is a Therapeutic Goal for Alzheimer's Disease. Annals of neurology 95 (4) (2024)
Mukesh Kumar, Noé Quittot, Simon Dujardin, Christoph N Schlaffner, Arthur Viode, Anne Wiedmer, Pieter Beerepoot, Joshua E Chun, Calina Glynn, Analiese R Fernandes, Cameron Donahue, Judith A Steen, Bradley T Hyman
Alzheimer proteopathic tau seeds are biochemically a forme fruste of mature paired helical filaments. Brain : a journal of neurology 147 (2) (2024)
Mukesh Kumar, Noé Quittot, Simon Dujardin, Christoph N Schlaffner, Arthur Viode, Anne Wiedmer, Pieter Beerepoot, Joshua E Chun, Calina Glynn, Analiese R Fernandes, Cameron Donahue, Judith A Steen, Bradley T Hyman
Alzheimer proteopathic tau seeds are biochemically a forme fruste of mature paired helical filaments. Brain : a journal of neurology 147 (2) (2024)
Theodore J Zwang, Rachel E Bennett, Maria Lysandrou, Benjamin Woost, Anqi Zhang, Charles M Lieber, Douglas S Richardson, Bradley T Hyman
Tissue libraries enable rapid determination of conditions that preserve antibody labeling in cleared mouse and human tissue. eLife 12 (2023)
Heather H C Lau, Iván Martínez-Valbuena, Raphaella W L So, Surabhi Mehra, Nicholas R G Silver, Alison Mao, Erica Stuart, Cian Schmitt-Ulms, Bradley T Hyman, Martin Ingelsson, Gábor G Kovács, Joel C Watts
The G51D SNCA mutation generates a slowly progressive α-synuclein strain in early-onset Parkinson's disease. Acta neuropathologica communications 11 (1) (2023)
Theodore J Zwang, Rachel E Bennett, Maria Lysandrou, Benjamin Woost, Anqi Zhang, Charles M Lieber, Douglas S Richardson, Bradley T Hyman
Tissue libraries enable rapid determination of conditions that preserve antibody labeling in cleared mouse and human tissue. eLife 12 (2023)
Theodore J Zwang, Rachel E Bennett, Maria Lysandrou, Benjamin Woost, Anqi Zhang, Charles M Lieber, Douglas S Richardson, Bradley T Hyman
Tissue libraries enable rapid determination of conditions that preserve antibody labeling in cleared mouse and human tissue. eLife 12 (2023)
Theodore J Zwang, Rachel E Bennett, Maria Lysandrou, Benjamin Woost, Anqi Zhang, Charles M Lieber, Douglas S Richardson, Bradley T Hyman
Tissue libraries enable rapid determination of conditions that preserve antibody labeling in cleared mouse and human tissue. eLife 12 (2023)
Calina Glynn, Joshua E Chun, Cameron C Donahue, Monica J S Nadler, Zhanyun Fan, Bradley T Hyman
Reconstitution of the Alzheimer's Disease Tau Core Structure from Recombinant Tau 297-391 Yields Variable Quaternary Structures as Seen by Negative Stain and Cryo-EM. Biochemistry 63 (2) (2023)
Jing Qian, Yiding Zhang, Rebecca A Betensky, Bradley T Hyman, Alberto Serrano-Pozo
Neuropathology-Independent Association Between APOE Genotype and Cognitive Decline Rate in the Normal Aging-Early Alzheimer Continuum. Neurology. Genetics 9 (1) (2023)
Theodore J Zwang, Rachel E Bennett, Maria Lysandrou, Benjamin Woost, Anqi Zhang, Charles M Lieber, Douglas S Richardson, Bradley T Hyman
Tissue libraries enable rapid determination of conditions that preserve antibody labeling in cleared mouse and human tissue. eLife 12 (2023)
Calina Glynn, Joshua E Chun, Cameron C Donahue, Monica J S Nadler, Zhanyun Fan, Bradley T Hyman
Reconstitution of the Alzheimer's Disease Tau Core Structure from Recombinant Tau 297-391 Yields Variable Quaternary Structures as Seen by Negative Stain and Cryo-EM. Biochemistry 63 (2) (2023)
Jing Qian, Yiding Zhang, Rebecca A Betensky, Bradley T Hyman, Alberto Serrano-Pozo
Neuropathology-Independent Association Between APOE Genotype and Cognitive Decline Rate in the Normal Aging-Early Alzheimer Continuum. Neurology. Genetics 9 (1) (2023)
Heather H C Lau, Iván Martínez-Valbuena, Raphaella W L So, Surabhi Mehra, Nicholas R G Silver, Alison Mao, Erica Stuart, Cian Schmitt-Ulms, Bradley T Hyman, Martin Ingelsson, Gábor G Kovács, Joel C Watts
The G51D SNCA mutation generates a slowly progressive α-synuclein strain in early-onset Parkinson's disease. Acta neuropathologica communications 11 (1) (2023)
Leonardo Garma, Lisbeth Harder, Juan Barba-Reyes, Monica Diez-Salguero, Alberto Serrano-Pozo, Bradley T Hyman, Ana Belén Muñoz-Manchado
Interneuron diversity in the human dorsal striatum. Research square (2023)
Harshvardhan Gazula, Henry F J Tregidgo, Benjamin Billot, Yael Balbastre, Jonathan William-Ramirez, Rogeny Herisse, Adrià Casamitjana, Erica J Melief, Caitlin S Latimer, Mitchell D Kilgore, Mark Montine, Eleanor Robinson, Emily Blackburn, Michael S Marshall, Theresa R Connors, Derek H Oakley, Matthew P Frosch, Koen Van Leemput, Adrian V Dalca, Bruce Fischl, Christine L Mac Donald, C Dirk Keene, Bradley T Hyman, Juan Eugenio Iglesias
3D analysis of dissection photographs with surface scanning and machine learning for quantitative neuropathology. bioRxiv : the preprint server for biology (2023)
Theodore J Zwang, Rachel E Bennett, Maria Lysandrou, Benjamin Woost, Anqi Zhang, Charles M Lieber, Douglas S Richardson, Bradley T Hyman
Tissue libraries enable rapid determination of conditions that preserve antibody labeling in cleared mouse and human tissue. eLife 12 (2023)
Theodore J Zwang, Rachel E Bennett, Maria Lysandrou, Benjamin Woost, Anqi Zhang, Charles M Lieber, Douglas S Richardson, Bradley T Hyman
Tissue libraries enable rapid determination of conditions that preserve antibody labeling in cleared mouse and human tissue. eLife 12 (2023)
Calina Glynn, Joshua E Chun, Cameron C Donahue, Monica J S Nadler, Zhanyun Fan, Bradley T Hyman
Reconstitution of the Alzheimer's Disease Tau Core Structure from Recombinant Tau 297-391 Yields Variable Quaternary Structures as Seen by Negative Stain and Cryo-EM. Biochemistry 63 (2) (2023)
Anastasie Mate De Gerando, Lindsay A Welikovitch, Anita Khasnavis, Caitlin Commins, Calina Glynn, Joshua E Chun, Romain Perbet, Bradley T Hyman
Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau. Acta neuropathologica (2023)
Theodore J Zwang, Rachel E Bennett, Maria Lysandrou, Benjamin Woost, Anqi Zhang, Charles M Lieber, Douglas S Richardson, Bradley T Hyman
Tissue libraries enable rapid determination of conditions that preserve antibody labeling in cleared mouse and human tissue. eLife 12 (2023)
Aurelien Lathuiliere, Youhwa Jo, Romain Perbet, Cameron Donahue, Caitlin Commins, Noé Quittot, Zhanyun Fan, Rachel E Bennett, Bradley T Hyman
Specific detection of tau seeding activity in Alzheimer's disease using rationally designed biosensor cells. Molecular neurodegeneration 18 (1) (2023)
Calina Glynn, Joshua E Chun, Cameron C Donahue, Monica J S Nadler, Zhanyun Fan, Bradley T Hyman
Reconstitution of the Alzheimer's Disease Tau Core Structure from Recombinant Tau 297-391 Yields Variable Quaternary Structures as Seen by Negative Stain and Cryo-EM. Biochemistry 63 (2) (2023)
Anastasie Mate de Gerando, Lindsay A Welikovitch, Anita Khasnavis, Caitlin Commins, Calina Glynn, Romain Perbet, Bradley T Hyman
Tau seeding and spreading in vivo is supported by both fibrillar and oligomeric tau. bioRxiv : the preprint server for biology (2023)
Heather H C Lau, Iván Martínez-Valbuena, Raphaella W L So, Surabhi Mehra, Nicholas R G Silver, Alison Mao, Erica Stuart, Cian Schmitt-Ulms, Bradley T Hyman, Martin Ingelsson, Gábor G Kovács, Joel C Watts
The G51D SNCA mutation generates a slowly progressive α-synuclein strain in early-onset Parkinson's disease. Acta neuropathologica communications 11 (1) (2023)
Jing Qian, Yiding Zhang, Rebecca A Betensky, Bradley T Hyman, Alberto Serrano-Pozo
Neuropathology-Independent Association Between APOE Genotype and Cognitive Decline Rate in the Normal Aging-Early Alzheimer Continuum. Neurology. Genetics 9 (1) (2023)
Calina Glynn, Joshua E Chun, Cameron C Donahue, Monica J S Nadler, Zhanyun Fan, Bradley T Hyman
Reconstitution of the Alzheimer's Disease Tau Core Structure from Recombinant Tau 297-391 Yields Variable Quaternary Structures as Seen by Negative Stain and Cryo-EM. Biochemistry 63 (2) (2023)
Jing Qian, Yiding Zhang, Rebecca A Betensky, Bradley T Hyman, Alberto Serrano-Pozo
Neuropathology-Independent Association Between APOE Genotype and Cognitive Decline Rate in the Normal Aging-Early Alzheimer Continuum. Neurology. Genetics 9 (1) (2023)
Theodore J Zwang, Rachel E Bennett, Maria Lysandrou, Benjamin Woost, Anqi Zhang, Charles M Lieber, Douglas S Richardson, Bradley T Hyman
Tissue libraries enable rapid determination of conditions that preserve antibody labeling in cleared mouse and human tissue. eLife 12 (2023)
Heather H C Lau, Iván Martínez-Valbuena, Raphaella W L So, Surabhi Mehra, Nicholas R G Silver, Alison Mao, Erica Stuart, Cian Schmitt-Ulms, Bradley T Hyman, Martin Ingelsson, Gábor G Kovács, Joel C Watts
The G51D SNCA mutation generates a slowly progressive α-synuclein strain in early-onset Parkinson's disease. Acta neuropathologica communications 11 (1) (2023)
Calina Glynn, Joshua E Chun, Cameron C Donahue, Monica J S Nadler, Zhanyun Fan, Bradley T Hyman
Reconstitution of the Alzheimer's Disease Tau Core Structure from Recombinant Tau 297-391 Yields Variable Quaternary Structures as Seen by Negative Stain and Cryo-EM. Biochemistry 63 (2) (2023)
Anastasie Mate de Gerando, Noe Quittot, Matthew P Frosch, Bradley T Hyman
Reply: Soluble oligomers or insoluble fibrils? Acta neuropathologica (2023)
Calina Glynn, Joshua E Chun, Cameron C Donahue, Monica J S Nadler, Zhanyun Fan, Bradley T Hyman
Reconstitution of the Alzheimer's Disease Tau Core Structure from Recombinant Tau 297-391 Yields Variable Quaternary Structures as Seen by Negative Stain and Cryo-EM. Biochemistry 63 (2) (2023)
Calina Glynn, Joshua E Chun, Cameron C Donahue, Monica J S Nadler, Zhanyun Fan, Bradley T Hyman
Reconstitution of the Alzheimer's Disease Tau Core Structure from Recombinant Tau 297-391 Yields Variable Quaternary Structures as Seen by Negative Stain and Cryo-EM. Biochemistry (2023)
Sudeshna Das, Zhaozhi Li, Astrid Wachter, Srinija Alla, Ayush Noori, Aicha Abdourahman, Joseph A Tamm, Maya E Woodbury, Robert V Talanian, Knut Biber, Eric H Karran, Bradley T Hyman, Alberto Serrano-Pozo
Distinct Transcriptomic Responses to Aβ plaques, Neurofibrillary Tangles, and APOE in Alzheimer's Disease. bioRxiv : the preprint server for biology (2023)
Marie-Laure Charpignon, Bella Vakulenko-Lagun, Bang Zheng, Colin Magdamo, Bowen Su, Kyle Evans, Steve Rodriguez, Artem Sokolov, Sarah A Boswell, Yi-Han Sheu, Melek Somai, Lefkos Middleton, Bradley T Hyman, Rebecca A Betensky, Stan N Finkelstein, Roy E Welsch, Joanna Tzoulaki, Deborah Blacker, Sudeshna Das, Mark W Albers
Causal inference in medical records and complementary systems pharmacology for metformin drug repurposing towards dementia. Nature communications 13 (1) (2022)
Marie-Laure Charpignon, Bella Vakulenko-Lagun, Bang Zheng, Colin Magdamo, Bowen Su, Kyle Evans, Steve Rodriguez, Artem Sokolov, Sarah A Boswell, Yi-Han Sheu, Melek Somai, Lefkos Middleton, Bradley T Hyman, Rebecca A Betensky, Stan N Finkelstein, Roy E Welsch, Joanna Tzoulaki, Deborah Blacker, Sudeshna Das, Mark W Albers
Causal inference in medical records and complementary systems pharmacology for metformin drug repurposing towards dementia. Nature communications 13 (1) (2022)
Marie-Laure Charpignon, Bella Vakulenko-Lagun, Bang Zheng, Colin Magdamo, Bowen Su, Kyle Evans, Steve Rodriguez, Artem Sokolov, Sarah A Boswell, Yi-Han Sheu, Melek Somai, Lefkos Middleton, Bradley T Hyman, Rebecca A Betensky, Stan N Finkelstein, Roy E Welsch, Joanna Tzoulaki, Deborah Blacker, Sudeshna Das, Mark W Albers
Causal inference in medical records and complementary systems pharmacology for metformin drug repurposing towards dementia. Nature communications 13 (1) (2022)
Marie-Laure Charpignon, Bella Vakulenko-Lagun, Bang Zheng, Colin Magdamo, Bowen Su, Kyle Evans, Steve Rodriguez, Artem Sokolov, Sarah A Boswell, Yi-Han Sheu, Melek Somai, Lefkos Middleton, Bradley T Hyman, Rebecca A Betensky, Stan N Finkelstein, Roy E Welsch, Joanna Tzoulaki, Deborah Blacker, Sudeshna Das, Mark W Albers
Causal inference in medical records and complementary systems pharmacology for metformin drug repurposing towards dementia. Nature communications 13 (1) (2022)
Marie-Laure Charpignon, Bella Vakulenko-Lagun, Bang Zheng, Colin Magdamo, Bowen Su, Kyle Evans, Steve Rodriguez, Artem Sokolov, Sarah A Boswell, Yi-Han Sheu, Melek Somai, Lefkos Middleton, Bradley T Hyman, Rebecca A Betensky, Stan N Finkelstein, Roy E Welsch, Joanna Tzoulaki, Deborah Blacker, Sudeshna Das, Mark W Albers
Causal inference in medical records and complementary systems pharmacology for metformin drug repurposing towards dementia. Nature communications 13 (1) (2022)
Marie-Laure Charpignon, Bella Vakulenko-Lagun, Bang Zheng, Colin Magdamo, Bowen Su, Kyle Evans, Steve Rodriguez, Artem Sokolov, Sarah A Boswell, Yi-Han Sheu, Melek Somai, Lefkos Middleton, Bradley T Hyman, Rebecca A Betensky, Stan N Finkelstein, Roy E Welsch, Joanna Tzoulaki, Deborah Blacker, Sudeshna Das, Mark W Albers
Causal inference in medical records and complementary systems pharmacology for metformin drug repurposing towards dementia. Nature communications 13 (1) (2022)
Ayush Noori, Colin Magdamo, Xiao Liu, Tanish Tyagi, Zhaozhi Li, Akhil Kondepudi, Haitham S Alabsi, Emily Rudmann, Douglas Wilcox, Laura N Brenner, Gregory K Robbins, Lidia M V R Moura, Sahar F Zafar, Nicole M Benson, John Hsu, John R Dickson, Alberto Serrano-Pozo, Bradley T Hyman, Deborah Blacker, Michael Brandon Westover, Shibani S Mukerji, Sudeshna Das
Development and Evaluation of a Natural Language Processing Annotation Tool to Facilitate Phenotyping of Cognitive Status in Electronic Health Records: Diagnostic Study. Journal of medical Internet research 24 (8) (2022)
Michael B Miller, August Yue Huang, Junho Kim, Zinan Zhou, Samantha L Kirkham, Eduardo A Maury, Jennifer S Ziegenfuss, Hannah C Reed, Jennifer E Neil, Lariza Rento, Steven C Ryu, Chanthia C Ma, Lovelace J Luquette, Heather M Ames, Derek H Oakley, Matthew P Frosch, Bradley T Hyman, Michael A Lodato, Eunjung Alice Lee, Christopher A Walsh
Somatic genomic changes in single Alzheimer's disease neurons. Nature 604 (7907) (2022)
Marie-Laure Charpignon, Bella Vakulenko-Lagun, Bang Zheng, Colin Magdamo, Bowen Su, Kyle Evans, Steve Rodriguez, Artem Sokolov, Sarah A Boswell, Yi-Han Sheu, Melek Somai, Lefkos Middleton, Bradley T Hyman, Rebecca A Betensky, Stan N Finkelstein, Roy E Welsch, Joanna Tzoulaki, Deborah Blacker, Sudeshna Das, Mark W Albers
Causal inference in medical records and complementary systems pharmacology for metformin drug repurposing towards dementia. Nature communications 13 (1) (2022)
Alberto Serrano-Pozo, Zhaozhi Li, Ayush Noori, Huong N Nguyen, Aziz Mezlini, Liang Li, Eloise Hudry, Rosemary J Jackson, Bradley T Hyman, Sudeshna Das
Effect of APOE alleles on the glial transcriptome in normal aging and Alzheimer's disease. Nature aging 1 (10) (2021)
Benjamin Caballero, Mathieu Bourdenx, Enrique Luengo, Antonio Diaz, Peter Dongmin Sohn, Xu Chen, Chao Wang, Yves R Juste, Susanne Wegmann, Bindi Patel, Zapporah T Young, Szu Yu Kuo, Jose Antonio Rodriguez-Navarro, Hao Shao, Manuela G López, Celeste M Karch, Alison Mary Goate, Jason E Gestwicki, Bradley T Hyman, Li Gan, Ana Maria Cuervo
Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice. Nature communications 12 (1) (2021)
Georg Meisl, Eric Hidari, Kieren Allinson, Timothy Rittman, Sarah L DeVos, Justin S Sanchez, Catherine K Xu, Karen E Duff, Keith A Johnson, James Benedict Rowe, Bradley T Hyman, Tuomas P J Knowles, David Klenerman
In vivo rate-determining steps of tau seed accumulation in Alzheimer's disease. Science advances 7 (44) (2021)
Steve Rodriguez, Clemens B Hug, Petar V Todorov, Nienke Moret, Sarah A Boswell, Kyle Evans, George Zhou, Nathan T Johnson, Bradley T Hyman, Peter Karl Sorger, Mark W Albers, Artem Sokolov
Machine learning identifies candidates for drug repurposing in Alzheimer's disease. Nature communications 12 (1) (2021)
George Devitt, Anna Crisford, William Rice, Hilary A Weismiller, Zhanyun Fan, Caitlin Commins, Bradley T Hyman, Martin Margittai, Sumeet Mahajan, Amritpal Mudher
Conformational fingerprinting of tau variants and strains by Raman spectroscopy. RSC advances 11 (15) (2021)
Alexandra Litvinchuk, Tien-Phat V Huynh, Yang Shi, Rosemary J Jackson, Mary B Finn, Melissa Manis, Caroline M Francis, Ainsley C Tran, Patrick M Sullivan, Jason D Ulrich, Bradley T Hyman, Tracy Cole, David M Holtzman
Apolipoprotein E4 Reduction with Antisense Oligonucleotides Decreases Neurodegeneration in a Tauopathy Model. Annals of neurology 89 (5) (2021)
Yuan Ma, Deborah Blacker, Anand Viswanathan, Susanne J van Veluw, Daniel Bos, Meike W Vernooij, Bradley T Hyman, Christophe Tzourio, Sudeshna Das, Albert Hofman
Visit-to-Visit Blood Pressure Variability, Neuropathology, and Cognitive Decline. Neurology 96 (23) (2021)
Susanne Wegmann, Sarah L DeVos, Bryan Zeitler, Kimberly Marlen, Rachel E Bennett, Marta Pérez-Rando, Danny McKenzie, Qi Yu, Caitlin Commins, Riley N Bannon, Bianca T Corjuc, Alison Chase, Lisa Diez, Hoang-Oanh B Nguyen, Sarah Hinkley, Lei Zhang, Alicia Goodwin, Annemarie Ledeboer, Stephen C Lam, Irina Ankoudinova, Hung Tran, Nicholas A Scarlott, Rainier Amora, Richard Surosky, Jeffrey C Miller, Ashley B Robbins, Edward J Rebar, Fyodor D Urnov, Michael C Holmes, Amy M Pooler, Brigit Riley, H Steve Zhang, Bradley T Hyman
Persistent repression of tau in the brain using engineered zinc finger protein transcription factors. Science advances 7 (12) (2021)
Steven Rodriguez, Asli Sahin, Benjamin R Schrank, Hawra Al Lawati, Isabel Costantino, Eric Benz, Darian Fard, Alefiya Dhilla Albers, Luxiang Cao, Alexis C Gomez, Kyle E Evans, Elena Ratti, Merit E Cudkowicz, Matthew P Frosch, Michael E Talkowski, Peter Karl Sorger, Bradley T Hyman, Mark W Albers
Genome-encoded cytoplasmic double-stranded RNAs, found in C9ORF72 ALS-FTD brain, propagate neuronal loss. Science translational medicine 13 (601) (2021)
Derek H Oakley, Naomi Klickstein, Caitlin Commins, Mirra Chung, Simon Dujardin, Rachel E Bennett, Bradley T Hyman, Matthew P Frosch
Continuous Monitoring of Tau-Induced Neurotoxicity in Patient-Derived iPSC-Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 41 (19) (2021)
David S Knopman, Helene Amieva, Ronald C Petersen, Gäel Chételat, David M Holtzman, Bradley T Hyman, Ralph A Nixon, David T Jones
Alzheimer disease. Nature reviews. Disease primers 7 (1) (2021)
Marta Perez-Rando, Simon Dujardin, Rachel E Bennett, Caitlin Commins, Tara Nibhanupudy, Bradley T Hyman
Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds. Acta neuropathologica communications 8 (1) (2020)
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Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study. Nature communications 11 (1) (2020)
Simon Dujardin, Caitlin Commins, Aurelien Lathuiliere, Pieter Beerepoot, Analiese R Fernandes, Tarun V Kamath, Mark B De Los Santos, Naomi Klickstein, Diana L Corjuc, Bianca T Corjuc, Patrick M Dooley, Arthur Viode, Derek H Oakley, Benjamin D Moore, Kristina Mullin, Dinorah Jean-Gilles, Ryan Clark, Kevin Atchison, Renee Moore, Lori B Chibnik, Rudolph E Tanzi, Matthew P Frosch, Alberto Serrano-Pozo, Fiona Elwood, Judith A Steen, Matthew E Kennedy, Bradley T Hyman
Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease. Nature medicine 26 (8) (2020)
Marc Aurel Busche, Bradley T Hyman
Synergy between amyloid-β and tau in Alzheimer's disease. Nature neuroscience 23 (10) (2020)
Jennifer N Rauch, Gabriel Luna, Elmer Guzman, Morgane Audouard, Collin Challis, Youssef E Sibih, Carolina Leshuk, Israel Hernandez, Susanne Wegmann, Bradley T Hyman, Viviana Gradinaru, Martin Edward Kampmann, Kenneth S Kosik
LRP1 is a master regulator of tau uptake and spread. Nature 580 (7803) (2020)
Angus Lau, Raphaella W L So, Heather H C Lau, Jason C Sang, Alejandro Iván Ruíz Riquelme, Shelaine C Fleck, Erica Stuart, Sindhu Menon, Naomi P Visanji, Georg Meisl, Rania Faidi, Maria M Marano, Cian Schmitt-Ulms, Zhilan Wang, Paul E Fraser, Anurag Tandon, Bradley T Hyman, Holger Wille, Martin Ingelsson, David Klenerman, Joel C Watts
α-Synuclein strains target distinct brain regions and cell types. Nature neuroscience 23 (1) (2019)
Christopher M Henstridge, Bradley T Hyman, Tara L Spires-Jones
Beyond the neuron-cellular interactions early in Alzheimer disease pathogenesis. Nature reviews. Neuroscience 20 (2) (2019)
Susanne Wegmann, Rachel E Bennett, Louis Delorme, Ashley B Robbins, Miwei Hu, Danny McKenzie, Molly J Kirk, Julia Schiantarelli, Nahel Tunio, Ana C Amaral, Zhanyun Fan, Samantha Nicholls, Eloise Hudry, Bradley T Hyman
Experimental evidence for the age dependence of tau protein spread in the brain. Science advances 5 (6) (2019)
Marc Aurel Busche, Susanne Wegmann, Simon Dujardin, Caitlin Commins, Julia Schiantarelli, Naomi Klickstein, Tarun V Kamath, George A Carlson, Israel Nelken, Bradley T Hyman
Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo. Nature neuroscience 22 (1) (2018)
Susanne Wegmann, Bahareh Eftekharzadeh, Katharina Tepper, Katarzyna M Zoltowska, Rachel E Bennett, Simon Dujardin, Pawel R Laskowski, Danny MacKenzie, Tarun Kamath, Caitlin Commins, Charles Vanderburg, Allyson D Roe, Zhanyun Fan, Amandine M Molliex, Amayra Hernandez-Vega, Daniel J Müller, Anthony A Hyman, Eckhard Mandelkow, J Paul Taylor, Bradley T Hyman
Tau protein liquid-liquid phase separation can initiate tau aggregation. The EMBO journal 37 (7) (2018)
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Entorhinal Cortex: Antemortem Cortical Thickness and Postmortem Neurofibrillary Tangles and Amyloid Pathology. AJNR. American journal of neuroradiology 38 (5) (2017)
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Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score. PLoS medicine 14 (3) (2017)