The Role of the NF-kB Pathway in Intracranial Aneurysms.
Laurentiu Andrei BlajAndrei Ionut CucuBogdan Ionel TambaMihaela Dana TurliucPublished in: Brain sciences (2023)
The pathophysiology of intracranial aneurysms (IA) has been proven to be closely linked to hemodynamic stress and inflammatory pathways, most notably the NF-kB pathway. Therefore, it is a potential target for therapeutic intervention. In the present review, we investigated alterations in the vascular smooth muscle cells (VSMCs), extracellular matrix, and endothelial cells by the mediators implicated in the NF-kB pathway that lead to the formation, growth, and rupture of IAs. We also present an overview of the NF-kB pathway, focusing on stimuli and transcriptional targets specific to IAs, as well as a summary of the current strategies for inhibiting NF-kB activation in IAs. Our report adds to previously reported data and future research directions for treating IAs using compounds that can suppress inflammation in the vascular wall.
Keyphrases
- signaling pathway
- lps induced
- oxidative stress
- vascular smooth muscle cells
- pi k akt
- extracellular matrix
- nuclear factor
- endothelial cells
- inflammatory response
- randomized controlled trial
- angiotensin ii
- electronic health record
- cell proliferation
- immune response
- transcription factor
- machine learning
- big data
- artificial intelligence
- stress induced
- current status
- human health
- single molecule
- data analysis