Red pepper seed water extract suppresses high-fat diet-induced obesity in C57BL/6 mice.
Hwa-Jin KimMi-Kyoung YouZiyun WangYoung-Hyeon LeeHyeon-A KimPublished in: Food science and biotechnology (2019)
In this study, the protective effect of red pepper seed water extract (RPS) against the obesity in high fat diet (HFD)-fed mice was investigated (HFD control group, and HFD group treated with 100 or 200 mg/kg body weight of RPS for 13 weeks). The application of RPS partially reversed the HFD-induced increases in body weight and adipose tissue weight. The patterns of the adipose tissue weights were parallel to the patterns of fat area, as measured in DXA procedure. In the adipose tissue, RPS suppressed the expression of adipogenic transcription factors and adipose marker genes. AMP-activated protein kinase activation was observed in the adipose tissue by RPS treatment. In addition, RPS improved high homeostasis model assessment of insulin resistance and hyperlipidemia in HFD fed mice. These findings suggest that RPS can be used as a potential therapeutic substance for reducing body fat and obesity related diseases.
Keyphrases
- high fat diet
- insulin resistance
- high fat diet induced
- adipose tissue
- body weight
- polycystic ovary syndrome
- metabolic syndrome
- protein kinase
- skeletal muscle
- transcription factor
- poor prognosis
- oxidative stress
- type diabetes
- signaling pathway
- body composition
- gene expression
- body mass index
- binding protein
- high glucose
- diabetic rats
- computed tomography
- weight loss
- weight gain
- high resolution
- endothelial cells
- gestational age