TRACEBACK: Testing of Historical Tubo-Ovarian Cancer Patients for Hereditary Risk Genes as a Cancer Prevention Strategy in Family Members.
Rachel DelahuntyLinh NguyenStuart CraigBelinda CreightonDinuka AriyaratneDale W GarsedElizabeth L ChristieSian FeredayLesley AndrewsAlexandra LewisSharne LimbAhwan PandeyJoy HendleyNadia TraficanteNatalia CarvajalAmanda B SpurdleBryony A ThompsonMichael T ParsonsVictoria BeshayMila VolcheckTimothy SempleRichard LupatKenneth D DoigJiaan YuXiao Qing ChenAnna MarshChristopher LoveSanela BilicMaria BeilinCassandra B NicholsChristina GreerYeh Chen LeeSusan GertyLynette GillEmma NewtonJulie HowardRachel WilliamsChristie NorrisAndrew N StephensErin TuttyCourtney SmythShona O'ConnellThomas JoblingColin J R StewartAdeline TanStephen B FoxNicholas PachterJason LiJason EllulGisela Mir ArnauMary-Anne YoungLouisa G GordonLaura ForrestMarion HarrisKaren LivingstoneJane HillGeorgia Chenevix-TrenchPaul Andrew CohenPenelope M WebbMichael L FriedlanderPaul A JamesDavid D L BowtellKathryn Alsopnull nullPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2022)
We overcame ethical and logistic challenges to demonstrate that retrospective genetic testing to identify PVs in previously untested deceased probands with TOC is feasible. Understanding reasons for a family member's decision to accept or decline a referral will be important for guiding future TRACEBACK projects.