Our study indicates that the low expression of SQLE employs adaptive survival through regulating the balance of apoptosis and ferroptosis resistance. In future, the combinational therapy of targeting SQLE and ferroptosis could be a promising approach in treating LUSC.
Keyphrases
- oxidative stress
- cell death
- squamous cell carcinoma
- cell cycle arrest
- poor prognosis
- endoplasmic reticulum stress
- dna damage
- induced apoptosis
- hydrogen peroxide
- cancer therapy
- diabetic rats
- binding protein
- nitric oxide
- free survival
- mesenchymal stem cells
- radiation therapy
- heat shock
- smoking cessation
- heat stress
- chemotherapy induced