Macrolide sesquiterpene pyridine alkaloids from the stems of Tripterygium regelii.
Dongsheng FanTing LiZhiyuan ZhengGuo-Yuan ZhuXiaojun YaoZhi-Hong JiangLi-Ping BaiPublished in: Journal of natural medicines (2018)
Nine new monomacrolide sesquiterpene pyridine alkaloids, macroregelines A-I (1-9), were isolated from the stems of Tripterygium regelii, along with a known alkaloid, tripfordine B. The structures of all the isolated compounds were characterized by extensive one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) spectroscopic analyses, as well as high-resolution electrospray-ionization mass spectrometry (HRESIMS) data. Compounds 4, 5, 6, and 8 showed antiproliferative effect on human rheumatoid arthritis synovial cell line MH7A at concentration of 20 μM, reducing their viability by 7.5, 18.0, 9.0, and 18.2 %, respectively.
Keyphrases
- high resolution
- magnetic resonance
- mass spectrometry
- rheumatoid arthritis
- endothelial cells
- molecular docking
- liquid chromatography
- electronic health record
- disease activity
- induced pluripotent stem cells
- big data
- high speed
- pluripotent stem cells
- gas chromatography
- contrast enhanced
- capillary electrophoresis
- tandem mass spectrometry
- magnetic resonance imaging
- machine learning
- interstitial lung disease