Clinical Cardiovascular Applications of Hyperpolarized Magnetic Resonance.
Andrew J M LewisDamian J TylerOliver RiderPublished in: Cardiovascular drugs and therapy (2020)
Current cardiovascular magnetic resonance imaging techniques provide an exquisite assessment of the structure and function of the heart and great vessels, but their ability to assess the molecular processes that underpin changes in cardiac function in health and disease is limited by inherent insensitivity. Hyperpolarized magnetic resonance is a new technology which overcomes this limitation, generating molecular contrast agents with an improvement in magnetic resonance signal of up to five orders of magnitude. One key molecule, hyperpolarized [1-13C]pyruvate, shows particular promise for the assessment of cardiac energy metabolism and other fundamental biological processes in cardiovascular disease. This molecule has numerous potential applications of clinical relevance and has now been translated to human use in early clinical studies. This review outlines the principles of hyperpolarized magnetic resonance and key potential cardiovascular applications for this new technology. Finally, we provide an overview of the pipeline for forthcoming hyperpolarized agents and their potential applications in cardiovascular disease.
Keyphrases
- magnetic resonance
- cardiovascular disease
- contrast enhanced
- magnetic resonance imaging
- human health
- type diabetes
- healthcare
- endothelial cells
- public health
- heart failure
- left ventricular
- risk assessment
- climate change
- cardiovascular risk factors
- metabolic syndrome
- big data
- cardiovascular events
- health information
- pluripotent stem cells
- clinical evaluation