Axl and immune checkpoints inhibitors from fruiting bodies of Pleurocybella porrigens.

Arif Yanuar RidwanJing WuEtsuko HaradaCorina N D Alessandro-GabazzaMasaaki TodaTaro YasumaEsteban C GabazzaJae-Hoon ChoiHirofumi HiraiHirokazu Kawagishi

Published in: The Journal of antibiotics (2020)

A novel compound (1) and three known ones (2-4) were isolated from the fruiting bodies of Pleurocybella porrigens. The structure of the novel compound was determined by 1D and 2D NMR and HRESIMS data. The biological activity of 1-3 was evaluated using the A549 lung cancer cell line. The results showed the inhibitory activity of compounds 1-3 on the expression of Axl and immune checkpoint molecules.

Keyphrases

tyrosine kinase
poor prognosis
magnetic resonance
high resolution
electronic health record
big data
binding protein
solid state
long non coding rna
data analysis
deep learning