Electrophysiology and Arrhythmogenesis in the Human Right Ventricular Outflow Tract.
Kedar K ArasAnna GamsNdeye Rokhaya FayeJaclyn A BrennanKatherine GoldrickJinghua LiYishan ZhongChia-Han ChiangElizabeth H SmithMegan D PostonJacqueline ChiversPeter HannaShunpei MoriOlujimi A AjijolaKalyanam ShivkumarDonald B HooverJonathan ViventiJohn A RogersOlivier BernusIgor R EfimovPublished in: Circulation. Arrhythmia and electrophysiology (2022)
Human RVOT electrophysiology is characterized by shorter action potential duration relative to the right ventricular apical region. Cholinergic right ventricular stimulation attenuates the arrhythmogenic effects of adrenergic stimulation, including increase in frequency of premature ventricular contractions and shortening of wavelength. Right ventricular arrhythmia is characterized by positive spatial-temporal autocorrelation between epicardial-endocardial arrhythmic wave fronts and rotors that are relatively more organized in the endocardium.