Identify Key Genes Correlated to Ischemia-Reperfusion Injury in Aging Livers.

Xijing Yan Jinliang Liang Xuejiao Li Zhongying Hu Jiahao Chen Jun Zheng Rong Li

Published in: Disease markers (2023)

We combined the expression profiling datasets of liver tissues and samples collected in our hospital for the first time to reveal that the changes in the expression of ARNTL, BTG2, CXCL10, CHI3L1, IER3, FOS, and PPARGC1A and the proportion of dendritic cells may be associated with aging livers being more prone to IRI. Nadroparin may be used to mitigate IRI in aging livers by targeting FOS, and regulation of DC activity may also reduce IRI.

Keyphrases

drug induced
dendritic cells
genome wide
adverse drug
poor prognosis
immune response
healthcare
gene expression
regulatory t cells
single cell
emergency department
transcription factor
long non coding rna
bioinformatics analysis