Photoactivated release of membrane impermeant sulfonates inside cells.

Stuart T Caldwell Sean N O'Byrne Calum WilsonFilip CvetkoMichael P Murphy John G McCarron Richard C Hartley

Published in: Chemical communications (Cambridge, England) (2021)

Photouncaging delivers compounds with high spatial and temporal control to induce or inhibit biological processes but the released compounds may diffuse out. We here demonstrate that sulfonate anions can be photocaged so that a membrane impermeable compound can enter cells, be uncaged by photoirradiation and trapped within the cell.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
cell death
oxidative stress
stem cells
cell therapy
bone marrow
high grade