X-ray computed microtomography datasets for osteogenic nanofibrous coated titanium implants.
Siddhartha DasKanchan DholamSandeep V GuravKiran BendaleArvind IngleBhabani MohantyPradip ChaudhariJayesh R BellarePublished in: Scientific data (2022)
Surface modifications of titanium implant influences the quality of osseointegration and are associated with favourable treatment prognosis in orthopaedic and cranio-maxillofacial cases. Hence, unlike previous works, the peri-implant region details of our novel osteogenic nanofibrous coated implants placed in rabbits (n = 6 + 1) were recorded over a 12-week period using a micro-CT imaging system. In this unique contribution, we have created a computed tomography (CT) library of rabbit's tibiae anatomy with osteogenic nanofibrous coated/uncoated implants and are introductory useful assets for investigating the correlation between osteogenic nanofibers coated implants and its effect on improved osseointegration. Apart from using this CT dataset to conduct serial 2D image studies, three-dimensional (3D) reconstructions, assessing segmentation algorithms and developing adequate image quantitation tools, there may be positive applications of these in comparative investigations of similar or related preclinical as well as future clinical studies, further design planning, development etc. required for evolution of implants beyond the present state of art.
Keyphrases
- dual energy
- computed tomography
- image quality
- mesenchymal stem cells
- soft tissue
- deep learning
- bone marrow
- contrast enhanced
- positron emission tomography
- high resolution
- magnetic resonance imaging
- machine learning
- mass spectrometry
- ms ms
- tissue engineering
- magnetic resonance
- liquid chromatography tandem mass spectrometry
- stem cells
- clinical trial
- cell therapy
- randomized controlled trial
- hiv infected
- diffusion weighted imaging
- liquid chromatography
- rna seq
- case control