Long non-coding RNA Tug1 modulates mitochondrial and myogenic responses to exercise in skeletal muscle.

Adam J TrewinJessica SilverHayley T DillonPaul A Della GattaLewan ParkerDanielle S HiamYin Peng LeeMark RichardsonGlenn D WadleySéverine Lamon

Published in: BMC biology (2022)

We found that TUG1 is upregulated in human skeletal muscle after a single session of exercise, and mechanistically, Tug1 regulates transcriptional networks associated with mitochondrial calcium handling, muscle differentiation and myogenesis. These data demonstrate that lncRNA Tug1 exerts regulation over fundamental aspects of skeletal muscle biology and response to exercise stimuli.

Keyphrases

skeletal muscle
long non coding rna
high intensity
insulin resistance
poor prognosis
physical activity
oxidative stress
resistance training
endothelial cells
gene expression
electronic health record
body composition
adipose tissue
machine learning
deep learning
metabolic syndrome
data analysis