Long non-coding RNA Tug1 modulates mitochondrial and myogenic responses to exercise in skeletal muscle.
Adam J TrewinJessica SilverHayley T DillonPaul A Della GattaLewan ParkerDanielle S HiamYin Peng LeeMark RichardsonGlenn D WadleySéverine LamonPublished in: BMC biology (2022)
We found that TUG1 is upregulated in human skeletal muscle after a single session of exercise, and mechanistically, Tug1 regulates transcriptional networks associated with mitochondrial calcium handling, muscle differentiation and myogenesis. These data demonstrate that lncRNA Tug1 exerts regulation over fundamental aspects of skeletal muscle biology and response to exercise stimuli.