Benefit and risk of intravenous alteplase in patients with acute large vessel occlusion stroke and low ASPECTS.
Gabriel BroocksRosalie McDonoughMatthias BechsteinUta HanningCaspar BrekenfeldFabian Alexander FlottmannHelge C KniepMarie Teresa NawkaMilani Deb-ChatterjiGötz ThomallaPeter SpornsLeonard Leong-Litt YeoBenjamin Yq TanAnil GopinathanAndreas KastrupMaria PolitiPanagiotis PapanagiotouAndre KemmlingFiehler JensLukas Meyernull nullPublished in: Journal of neurointerventional surgery (2022)
Bridging IVT in patients with low ASPECTS was associated with very poor functional outcome and an increased risk of sICH. The benefit of this treatment should therefore be carefully weighed in such scenarios. Further randomized controlled trials are required to validate our findings.