Effect of monthly high-dose vitamin D on bone density in community-dwelling older adults substudy of a randomized controlled trial.
Ian R ReidA M HorneB MihovG D GambleF Al-AbuwsiM SinghL TaylorS FenwickC A CamargoA W StewartR ScraggPublished in: Journal of internal medicine (2017)
This substudy finds no clinically important benefit to BMD from untargeted vitamin D supplementation of older, community-dwelling adults. Exploratory analyses suggest meaningful benefit in those with baseline 25-hydroxyvitamin D ≤ 30 nmol L-1 . This represents a significant step towards a trial-based definition of vitamin D deficiency for bone health in older adults.
Keyphrases
- community dwelling
- high dose
- bone mineral density
- healthcare
- public health
- physical activity
- soft tissue
- bone loss
- low dose
- bone regeneration
- study protocol
- mass spectrometry
- mental health
- stem cell transplantation
- liquid chromatography
- body composition
- health information
- gas chromatography mass spectrometry
- phase ii
- randomized controlled trial
- high resolution mass spectrometry
- health promotion
- risk assessment
- simultaneous determination
- solid phase extraction