Regulation of gingival fibroblast phenotype by periodontal ligament cells in vitro.

Devy F GarnaFrancis J HughesMandeep S Ghuman

Published in: Journal of periodontal research (2022)

PDL cells stimulate expression of periodontal markers and osteogenic capacity of gingival fibroblasts via paracrine signaling which can be partially inhibited with addition of the Wnt antagonist, Dkk1.Further studies are required to identify specific secreted factors responsible for this activity.

Keyphrases

induced apoptosis
cell cycle arrest
stem cells
poor prognosis
signaling pathway
oxidative stress