Small-molecule MMP2/MMP9 inhibitor SB-3CT modulates tumor immune surveillance by regulating PD-L1.

Youqiong YeXinwei KuangZuozhong XieLong LiangZhao ZhangYongchang ZhangFangyu MaQian GaoRuimin ChangHeng-Huan LeeShuang ZhaoJuan SuHui LiJingbo PengHuifang ChenMinzhu YinCong PengNong YangJing WangJing LiuHong LiuLeng HanXiang Chen

Published in: Genome medicine (2020)

Our study unraveled novel molecular mechanisms regarding the regulation of tumor PD-L1 and provided a novel combination therapeutic strategy of SB-3CT and ICB therapy to enhance the efficacy of immunotherapy.

Keyphrases

small molecule
image quality
computed tomography
dual energy
contrast enhanced
public health
cell migration
positron emission tomography
magnetic resonance imaging
stem cells
magnetic resonance
mesenchymal stem cells
replacement therapy