Inhibition of Renin Expression Is Regulated by an Epigenetic Switch From an Active to a Poised State.
Jason P SmithRobert PaxtonSilvia MedranoNathan C SheffieldMaria Luisa S Sequeira-LopezR Ariel GomezPublished in: Hypertension (Dallas, Tex. : 1979) (2024)
Inhibition of renin expression in cells that constitutively synthesize and release renin is regulated by an epigenetic switch from an active to poised state associated with decreased cell-cell communication and an epithelial-mesenchymal transition. This work highlights and helps define the factors necessary for renin cells to alternate between myoendocrine and contractile phenotypes.
Keyphrases
- induced apoptosis
- epithelial mesenchymal transition
- poor prognosis
- angiotensin converting enzyme
- cell cycle arrest
- single cell
- dna methylation
- gene expression
- cell therapy
- signaling pathway
- skeletal muscle
- oxidative stress
- endoplasmic reticulum stress
- stem cells
- angiotensin ii
- bone marrow
- mesenchymal stem cells
- cell proliferation