The Oncogenic Role of miR-BART19-3p in Epstein-Barr Virus-Associated Diseases.
Qingxun ZhangDonghua LuoZhengde XieHongxuan HeZiyuan DuanPublished in: BioMed research international (2020)
Accumulating evidence so far has shown that EBV's miRNAs have been found to be involved in cancer progression. However, the comprehensive EBV miRNA expression profiles and their biological significance in EBV-associated diseases are not well documented. A comprehensive profiling of EBV-encoded miRNAs expressed in CAEBV, EBV-HLH, and nasopharyngeal carcinoma (NPC) patients was constructed, and the results showed that miR-BART19-3p was upregulated in all these diseases. Ectopic expression of miR-BART19-3p induced EBV-negative cell proliferation and suppressed cell apoptosis. Molecularly, adenomatous polyposis coli (APC) was identified to be a direct target of miR-BART19-3p, and APC mRNA expression was inversely correlated with miR-BART19-3p in CAEBV samples. Our results demonstrated that miR-BART19-3p contributes to the tumorigenesis of EBV-associated diseases and may be a potential therapeutic target.
Keyphrases
- epstein barr virus
- cell proliferation
- diffuse large b cell lymphoma
- long non coding rna
- long noncoding rna
- cell cycle
- poor prognosis
- risk assessment
- end stage renal disease
- squamous cell carcinoma
- wastewater treatment
- prognostic factors
- newly diagnosed
- young adults
- papillary thyroid
- peritoneal dialysis
- patient reported outcomes
- patient reported