DNA methylation profiles of immune response-related genes in apical periodontitis.

C WichnieskiK MaheshwariLetícia Chaves de SouzaF NievesTalita TartariG P GarletEverdan CarneiroA LetraR M Silva

Published in: International endodontic journal (2018)

Differential methylation profiles of immune response-related genes, such as FADD, CXCL3, IL12B and IL4R, may have an influence on individual AP susceptibility and patient treatment outcomes, through their potential contributions to altered expression of disease-relevant genes. Methylation and/or genetic variations in additional genes may also contribute to the dynamics of AP development and should be considered in future studies.

Keyphrases

genome wide
dna methylation
immune response
transcription factor
copy number
gene expression
poor prognosis
dendritic cells
toll like receptor
risk assessment
case control
inflammatory response
long non coding rna
human health