Limited impact of Delta variant’s mutations in the effectiveness of neutralization conferred by natural infection or COVID-19 vaccines in a Latino population.
Carlos A A SariolCrisanta Serrano-CollazoEdwin J OrtizPetraleigh PantojaLorna CruzTeresa AranaDianne AtehortuaChristina Pabon-CarreroAna M EspinoPublished in: medRxiv : the preprint server for health sciences (2021)
The SARS-CoV-2 pandemic has impacted public health systems all over the world. The Delta variant seems to possess enhanced transmissibility, but no clear evidence suggests it has increased virulence. Our data shows that pre-exposed individuals had similar neutralizing activity against the authentic COVID-19 strain and the Delta and Epsilon variants. After one vaccine dose, the neutralization capacity expands to all tested variants. Healthy vaccinated individuals showed a limited breadth of neutralization. One vaccine dose induced similar neutralizing antibodies against the Delta compared to the authentic strain. However, even after two doses, this capacity only expanded to the Epsilon variant.
Keyphrases
- sars cov
- coronavirus disease
- respiratory syndrome coronavirus
- copy number
- escherichia coli
- randomized controlled trial
- systematic review
- healthcare
- dengue virus
- high glucose
- electronic health record
- diabetic rats
- genome wide
- zika virus
- data analysis
- cystic fibrosis
- big data
- endothelial cells
- aedes aegypti
- african american