Multi-omics reveals age-related differences in the diaphragm response to mechanical ventilation: a pilot study.
Qiong LyuYa WenXiang ZhangAlex B AddinsallNicola CaccianiLars LarssonPublished in: Skeletal muscle (2021)
The dramatically increased mortality in old ICU patients with COVID-19-associated hyperinflammation and cytokine storm need not only reflect the viral infection but may also be associated with the ventilator induced diaphragm dysfunction (VIDD) and hyperinflammatory responses induced by long-term CMV per se. Although mechanical ventilation is a life-saving intervention in COVID-19 ICU patients, CMV should be cautiously used especially in old age and other means of respiratory support may be considered, such as negative pressure ventilation.
Keyphrases
- mechanical ventilation
- acute respiratory distress syndrome
- intensive care unit
- respiratory failure
- end stage renal disease
- coronavirus disease
- ejection fraction
- randomized controlled trial
- sars cov
- newly diagnosed
- chronic kidney disease
- extracorporeal membrane oxygenation
- prognostic factors
- peritoneal dialysis
- oxidative stress
- high glucose
- cardiovascular events
- type diabetes
- diabetic rats
- patient reported outcomes
- coronary artery disease
- drug induced