Andrographolide-loaded solid lipid nanoparticles enhance anti-cancer activity against head and neck cancer and precancerous cells.

Hongquan LiXingzhou QuWenhao QianYang SongChanghong WangWei Liu

Published in: Oral diseases (2020)

Our preliminary study demonstrates that ADG-SLN exhibits superior inhibitory activity against head and neck cancer and precancerous cells compared with free ADG. This effect is due to the higher efficiency of cellular uptake and intracellular absorption by ADG-SLN.

Keyphrases

induced apoptosis
cell cycle arrest
drug delivery
endoplasmic reticulum stress
signaling pathway
cell proliferation
oxidative stress
cancer therapy
radiation therapy
lymph node
reactive oxygen species
pi k akt
early stage
neoadjuvant chemotherapy
fatty acid