Levetiracetam in lactation: How much is excreted into human breast milk?

Natalie DinavitserElkana KohnMaya BerlinNurit BrandrissAdina Bar-ChaimRimona KeidarAyelet LivneDavid StepenskyMatitiahu BerkovitchRevital Sheinberg

Published in: British journal of clinical pharmacology (2021)

Infant levetiracetam exposure via the breastmilk was close to the safety thresholds (trough breastmilk/serum ratio slightly below 1, RID > 10% in fully breastfed infants), and infant somnolescence reports could be related to exposure of the infants to levetiracetam via breastmilk. Further studies are warranted to reveal the short- and long-term safety of levetiracetam in breastfeeding.

Keyphrases

endothelial cells
preterm infants
human milk
emergency department
dna methylation
dairy cows
single cell
pluripotent stem cells
adverse drug
drug induced