MRP3-Mediated Chemoresistance in Cholangiocarcinoma: Target for Chemosensitization Through Restoring SOX17 Expression.

Elisa LozanoMaitane AsensioLaura Perez-SilvaJesus M BanalesOscar BrizJose J G Marin

Published in: Hepatology (Baltimore, Md.) (2020)

SOX9/2/17 are involved in MRP3-mediated CCA chemoresistance. Restored SOX17 expression, in addition to its tumor suppression effect, induces selective chemosensitization due to MRP3 down-regulation and subsequent intracellular drug accumulation.

Keyphrases

poor prognosis
transcription factor
stem cells
emergency department
reactive oxygen species
drug induced