Activation of thyroid hormone receptor-β improved disease activity and metabolism independent of body weight in a mouse model of non-alcoholic steatohepatitis and fibrosis.

Aimo KanntPaulus WohlfartAndreas Nygaard MadsenSanne Skovgård VeidalMichael FeighDieter Schmoll

Published in: British journal of pharmacology (2021)

Our model robustly reflected clinical observations of body weight-independent improvements in systemic and hepatic metabolism including anti-steatotic activity.

Keyphrases

body weight
disease activity
systemic lupus erythematosus
rheumatoid arthritis
mouse model
rheumatoid arthritis patients
ankylosing spondylitis
juvenile idiopathic arthritis
liver injury
drug induced