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Genome-wide association studies identify novel genetic loci for epigenetic age acceleration among survivors of childhood cancer.

Qian DongNan SongNa QinCheng ChenZhenghong LiXiaojun SunJohn EastonHeather MulderEmily PlylerGeoffrey NealeEmily WalkerQian LiXiaotu MaXiang ChenI-Chan HuangYutaka YasuiKirsten K NessJinghui ZhangMelissa M HudsonLeslie L RobisonZhaoming Wang
Published in: Genome medicine (2022)
We identified novel genetic variants in the SELP gene and HLA region associated with EAA-Horvath and EAA-Hannum, respectively, among survivors of childhood cancer. The new genetic variants in combination with other replicated known variants can facilitate the identification of survivors at higher risk in developing accelerated aging and potentially inform drug targets for future intervention strategies among vulnerable survivors.
Keyphrases
  • childhood cancer
  • young adults
  • genome wide association
  • genome wide
  • copy number
  • dna methylation
  • randomized controlled trial
  • gene expression
  • emergency department
  • current status
  • adverse drug
  • bioinformatics analysis