MiR-1-3p that correlates with left ventricular function of HCM can serve as a potential target and differentiate HCM from DCM.
Mengmeng LiXiao ChenLiang ChenKai ChenJianye ZhouJiang-Ping SongPublished in: Journal of translational medicine (2018)
Our data demonstrated that different cardiomyopathies had unique miRNA expression pattern. And the expression levels of miR-1-3p and miR-27a had disease-specificity and sensitivity in HCM, whereas only miR-1-3p was significantly associated with left ventricular function in HCM identifying it as a potential target to improve the cardiac function in end-stage HCM. We also provide Clcn3 as a direct target of miR-1-3p which sheds light on the mechanism of HCM.
Keyphrases
- hypertrophic cardiomyopathy
- left ventricular
- poor prognosis
- heart failure
- cardiac resynchronization therapy
- acute myocardial infarction
- long non coding rna
- mitral valve
- aortic stenosis
- left atrial
- cell proliferation
- binding protein
- big data
- long noncoding rna
- transcatheter aortic valve replacement
- deep learning
- atrial fibrillation