Human milk oligosaccharide 2'-fucosyllactose protects against high-fat diet-induced obesity by changing intestinal mucus production, composition and degradation linked to changes in gut microbiota and faecal proteome profiles in mice.
Paola PaoneDimitrios LatousakisRomano TerrasiDidier VertommenChing JianValentina BorlandelliFrancesco SurianoMalin E V JohanssonAnthony PuelCaroline BouzinNathalie M DelzenneAnne SalonenNathalie JugeBogdan I FloreaGiulio G MuccioliHerman S OverkleeftMatthias Van HulPatrice D CaniPublished in: Gut (2024)
Our results show that the HMO 2'FL influences host metabolism by modulating the mucus layer, gut microbiota and eCB system and propose the mucus layer as a new potential target for the prevention of obesity and related disorders.