Herman S Overkleeft (H S Overkleeft, Hermen Overkleeft, Herman Overkleeft, Hermen S Overkleeft)

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 94

Top Topics

Molecular Docking

Multiple Myeloma

Endoplasmic Reticulum

Top Venues

Journal of the American Chemical Society

Chemistry (Weinheim an der Bergstrasse, Germany)

Proceedings of the National Academy of Sciences of the United States of America

Chemical science

This page only lists publications with an associated author ORCID identifier.

Publications

William C Hou, Lynée A Massey, Derek Rhoades, Yin Wu, Wen Ren, Chiara Frank, Herman S Overkleeft, Jeffrey W Kelly
A PIKfyve modulator combined with an integrated stress response inhibitor to treat lysosomal storage diseases. Proceedings of the National Academy of Sciences of the United States of America 121 (34) (2024)
Marta Artola, Johannes M F G Aerts, Gijsbert A van der Marel, Carme Rovira, Jeroen D C Codée, Gideon J Davies, Herman S Overkleeft
From Mechanism-Based Retaining Glycosidase Inhibitors to Activity-Based Glycosidase Profiling. Journal of the American Chemical Society (2024)
William C Hou, Lynée A Massey, Derek Rhoades, Yin Wu, Wen Ren, Chiara Frank, Herman S Overkleeft, Jeffrey W Kelly
A PIKfyve modulator combined with an integrated stress response inhibitor to treat lysosomal storage diseases. Proceedings of the National Academy of Sciences of the United States of America 121 (34) (2024)
Melissa Thaler, Tim P Ofman, Ken Kok, Jurriaan J A Heming, Elisha Moran, Isabelle Pickles, Anouk A Leijs, Adrianus M C H van den Nieuwendijk, Richard J B H N van den Berg, Gijs Ruijgrok, Zach W B Armstrong, Clarisse Salgado-Benvindo, Dennis K Ninaber, Eric J Snijder, Constant A A van Boeckel, Marta Artola, Gideon J Davies, Herman S Overkleeft, Martijn J van Hemert
Epi -Cyclophellitol Cyclosulfate, a Mechanism-Based Endoplasmic Reticulum α-Glucosidase II Inhibitor, Blocks Replication of SARS-CoV-2 and Other Coronaviruses. ACS central science 10 (8) (2024)
William C Hou, Lynée A Massey, Derek Rhoades, Yin Wu, Wen Ren, Chiara Frank, Herman S Overkleeft, Jeffrey W Kelly
A PIKfyve modulator combined with an integrated stress response inhibitor to treat lysosomal storage diseases. Proceedings of the National Academy of Sciences of the United States of America 121 (34) (2024)
Tim P Ofman, Jurriaan J A Heming, Alba Nin-Hill, Florian Küllmer, Elisha Moran, Megan Bennett, Roy Steneker, Anne-Mei Klein, Gijs Ruijgrok, Ken Kok, Zach W B Armstrong, Johannes M F G Aerts, Gijsbert A van der Marel, Carme Rovira, Gideon J Davies, Marta Artola, Jeroen D C Codée, Herman S Overkleeft
Conformational and Electronic Variations in 1,2- and 1,5a-Cyclophellitols and their Impact on Retaining α-Glucosidase Inhibition. Chemistry (Weinheim an der Bergstrasse, Germany) (2024)
Paola Paone, Dimitrios Latousakis, Romano Terrasi, Didier Vertommen, Ching Jian, Valentina Borlandelli, Francesco Suriano, Malin E V Johansson, Anthony Puel, Caroline Bouzin, Nathalie M Delzenne, Anne Salonen, Nathalie Juge, Bogdan I Florea, Giulio G Muccioli, Herman S Overkleeft, Matthias Van Hul, Patrice D Cani
Human milk oligosaccharide 2'-fucosyllactose protects against high-fat diet-induced obesity by changing intestinal mucus production, composition and degradation linked to changes in gut microbiota and faecal proteome profiles in mice. Gut (2024)
William C Hou, Lynée A Massey, Derek Rhoades, Yin Wu, Wen Ren, Chiara Frank, Herman S Overkleeft, Jeffrey W Kelly
A PIKfyve modulator combined with an integrated stress response inhibitor to treat lysosomal storage diseases. Proceedings of the National Academy of Sciences of the United States of America 121 (34) (2024)
Melissa Thaler, Tim P Ofman, Ken Kok, Jurriaan J A Heming, Elisha Moran, Isabelle Pickles, Anouk A Leijs, Adrianus M C H van den Nieuwendijk, Richard J B H N van den Berg, Gijs Ruijgrok, Zach W B Armstrong, Clarisse Salgado-Benvindo, Dennis K Ninaber, Eric J Snijder, Constant A A van Boeckel, Marta Artola, Gideon J Davies, Herman S Overkleeft, Martijn J van Hemert
Epi -Cyclophellitol Cyclosulfate, a Mechanism-Based Endoplasmic Reticulum α-Glucosidase II Inhibitor, Blocks Replication of SARS-CoV-2 and Other Coronaviruses. ACS central science 10 (8) (2024)
William C Hou, Lynée A Massey, Derek Rhoades, Yin Wu, Wen Ren, Chiara Frank, Herman S Overkleeft, Jeffrey W Kelly
A PIKfyve modulator combined with an integrated stress response inhibitor to treat lysosomal storage diseases. Proceedings of the National Academy of Sciences of the United States of America 121 (34) (2024)
Amanda L Graboski, Joshua B Simpson, Samuel J Pellock, Naimee Mehta, Benjamin C Creekmore, Yamuna Ariyarathna, Aadra P Bhatt, Parth B Jariwala, Josh J Sekela, Mark E Kowalewski, Natalie K Barker, Angie L Mordant, Valentina B Borlandelli, Herman S Overkleeft, Laura E Herring, Jian Jin, Lindsey I James, Matthew R Redinbo
Advanced piperazine-containing inhibitors target microbial β-glucuronidases linked to gut toxicity. RSC chemical biology 5 (9) (2024)
Tim P Ofman, Jurriaan J A Heming, Alba Nin-Hill, Florian Küllmer, Elisha Moran, Megan Bennett, Roy Steneker, Anne-Mei Klein, Gijs Ruijgrok, Ken Kok, Zach W B Armstrong, Johannes M F G Aerts, Gijsbert A van der Marel, Carme Rovira, Gideon J Davies, Marta Artola, Jeroen D C Codée, Herman S Overkleeft
Conformational and Electronic Variations in 1,2- and 1,5a-Cyclophellitols and their Impact on Retaining α-Glucosidase Inhibition. Chemistry (Weinheim an der Bergstrasse, Germany) 30 (31) (2024)
Qin Su, Max Louwerse, Rob F Lammers, Elmer Maurits, Max Janssen, Rolf G Boot, Valentina Borlandelli, Wendy A Offen, Daniël Linzel, Sybrin P Schröder, Gideon J Davies, Herman S Overkleeft, Marta Artola, Johannes M F G Aerts
Selective labelling of GBA2 in cells with fluorescent β-d-arabinofuranosyl cyclitol aziridines. Chemical science (2024)
Tim P Ofman, Jurriaan J A Heming, Alba Nin-Hill, Florian Küllmer, Elisha Moran, Megan Bennett, Roy Steneker, Anne-Mei Klein, Gijs Ruijgrok, Ken Kok, Zach W B Armstrong, Johannes M F G Aerts, Gijsbert A van der Marel, Carme Rovira, Gideon J Davies, Marta Artola, Jeroen D C Codée, Herman S Overkleeft
Conformational and Electronic Variations in 1,2- and 1,5a-Cyclophellitols and their Impact on Retaining α-Glucosidase Inhibition. Chemistry (Weinheim an der Bergstrasse, Germany) 30 (31) (2024)
Yurong Chen, Adrianus M C H van den Nieuwendijk, Liang Wu, Elisha Moran, Foteini Skoulikopoulou, Vera van Riet, Herman S Overkleeft, Gideon J Davies, Zach W B Armstrong
Molecular Basis for Inhibition of Heparanases and β-Glucuronidases by Siastatin B. Journal of the American Chemical Society 146 (1) (2023)
Jacob M A van Hengst, Rik J C Hellemons, Wouter A Remmerswaal, Koen N A van de Vrande, Thomas Hansen, Stefan van der Vorm, Herman S Overkleeft, Gijsbert A van der Marel, Jeroen D C Codée
Mapping the effect of configuration and protecting group pattern on glycosyl acceptor reactivity. Chemical science 14 (6) (2023)
Valentina Borlandelli, Zachary Armstrong, Alba Nin-Hill, Jeroen D C Codée, Lluís Raich, Marta Artola, Carme Rovira, Gideon J Davies, Herman S Overkleeft
4-O-Substituted Glucuronic Cyclophellitols are Selective Mechanism-Based Heparanase Inhibitors. ChemMedChem 18 (4) (2023)
Chi-Lin Kuo, Qin Su, Adrianus M C H van den Nieuwendijk, Thomas J M Beenakker, Wendy A Offen, Lianne I Willems, Rolf G Boot, Alexi J Sarris, André R A Marques, Jeroen D C Codée, Gijsbert A van der Marel, Bogdan I Florea, Gideon J Davies, Herman S Overkleeft, Johannes M F G Aerts
The development of a broad-spectrum retaining β-exo-galactosidase activity-based probe. Organic & biomolecular chemistry (2023)
Valentina Borlandelli, Zachary Armstrong, Alba Nin-Hill, Jeroen D C Codée, Lluís Raich, Marta Artola, Carme Rovira, Gideon J Davies, Herman S Overkleeft
4-O-Substituted Glucuronic Cyclophellitols are Selective Mechanism-Based Heparanase Inhibitors. ChemMedChem 18 (4) (2023)
Yurong Chen, Adrianus M C H van den Nieuwendijk, Liang Wu, Elisha Moran, Foteini Skoulikopoulou, Vera van Riet, Herman S Overkleeft, Gideon J Davies, Zach W B Armstrong
Molecular Basis for Inhibition of Heparanases and β-Glucuronidases by Siastatin B. Journal of the American Chemical Society 146 (1) (2023)
Rosalie Lipsh-Sokolik, Olga Khersonsky, Sybrin P Schröder, Casper de Boer, Shlomo Yakir Hoch, Gideon J Davies, Herman S Overkleeft, Sarel Jacob Fleishman
Combinatorial assembly and design of enzymes. Science (New York, N.Y.) 379 (6628) (2023)
Yurong Chen, Adrianus M C H van den Nieuwendijk, Liang Wu, Elisha Moran, Foteini Skoulikopoulou, Vera van Riet, Herman S Overkleeft, Gideon J Davies, Zach W B Armstrong
Molecular Basis for Inhibition of Heparanases and β-Glucuronidases by Siastatin B. Journal of the American Chemical Society 146 (1) (2023)
Yurong Chen, Adrianus M C H van den Nieuwendijk, Liang Wu, Elisha Moran, Foteini Skoulikopoulou, Vera van Riet, Herman S Overkleeft, Gideon J Davies, Zach W B Armstrong
Molecular Basis for Inhibition of Heparanases and β-Glucuronidases by Siastatin B. Journal of the American Chemical Society 146 (1) (2023)
Yurong Chen, Adrianus M C H van den Nieuwendijk, Liang Wu, Elisha Moran, Foteini Skoulikopoulou, Vera van Riet, Herman S Overkleeft, Gideon J Davies, Zach W B Armstrong
Molecular Basis for Inhibition of Heparanases and β-Glucuronidases by Siastatin B. Journal of the American Chemical Society 146 (1) (2023)
Jacob M A van Hengst, Rik J C Hellemons, Wouter A Remmerswaal, Koen N A van de Vrande, Thomas Hansen, Stefan van der Vorm, Herman S Overkleeft, Gijsbert A van der Marel, Jeroen D C Codée
Mapping the effect of configuration and protecting group pattern on glycosyl acceptor reactivity. Chemical science 14 (6) (2023)
Valentina Borlandelli, Wendy Offen, Olga Moroz, Alba Nin-Hill, Nicholas McGregor, Lars Binkhorst, Akihiro Ishiwata, Zach W B Armstrong, Marta Artola, Carme Rovira, Gideon J Davies, Herman S Overkleeft
β-l- Arabino furano-cyclitol Aziridines Are Covalent Broad-Spectrum Inhibitors and Activity-Based Probes for Retaining β-l-Arabinofuranosidases. ACS chemical biology (2023)
Valentina Borlandelli, Zachary Armstrong, Alba Nin-Hill, Jeroen D C Codée, Lluís Raich, Marta Artola, Carme Rovira, Gideon J Davies, Herman S Overkleeft
4-O-Substituted Glucuronic Cyclophellitols are Selective Mechanism-Based Heparanase Inhibitors. ChemMedChem 18 (4) (2023)
Daniël van der Gracht, Rhianna J Rowland, Véronique Roig-Zamboni, Maria J Ferraz, Max Louwerse, Paul P Geurink, Johannes M F G Aerts, Gerlind Sulzenbacher, Gideon J Davies, Herman S Overkleeft, Marta Artola
Fluorescence polarisation activity-based protein profiling for the identification of deoxynojirimycin-type inhibitors selective for lysosomal retaining alpha- and beta-glucosidases. Chemical science 14 (34) (2023)
Yurong Chen, Adrianus M C H van den Nieuwendijk, Liang Wu, Elisha Moran, Foteini Skoulikopoulou, Vera van Riet, Herman S Overkleeft, Gideon J Davies, Zach W B Armstrong
Molecular Basis for Inhibition of Heparanases and β-Glucuronidases by Siastatin B. Journal of the American Chemical Society 146 (1) (2023)
Nicholas G S McGregor, Casper de Boer, Quentin P O Foucart, Thomas J M Beenakker, Wendy A Offen, Jeroen D C Codée, Lianne I Willems, Herman S Overkleeft, Gideon J Davies
A Multiplexing Activity-Based Protein-Profiling Platform for Dissection of a Native Bacterial Xyloglucan-Degrading System. ACS central science 9 (12) (2023)
Yurong Chen, Adrianus M C H van den Nieuwendijk, Liang Wu, Elisha Moran, Foteini Skoulikopoulou, Vera van Riet, Herman S Overkleeft, Gideon J Davies, Zach W B Armstrong
Molecular Basis for Inhibition of Heparanases and β-Glucuronidases by Siastatin B. Journal of the American Chemical Society (2023)
Rosalie Lipsh-Sokolik, Olga Khersonsky, Sybrin P Schröder, Casper de Boer, Shlomo Yakir Hoch, Gideon J Davies, Herman S Overkleeft, Sarel Jacob Fleishman
Combinatorial assembly and design of enzymes. Science (New York, N.Y.) 379 (6628) (2023)
Sven Wijngaarden, Chunsong Yang, Carlos Vela-Rodríguez, Lari Lehtiö, Herman S Overkleeft, Bryce M Paschal, Dmitri V Filippov
Synthetic Dual Cysteine-ADP Ribosylated Peptides from the Androgen Receptor are Recognized by the DTX3L/PARP9 Complex. ACS chemical biology (2023)
Rosalie Lipsh-Sokolik, Olga Khersonsky, Sybrin P Schröder, Casper de Boer, Shlomo Yakir Hoch, Gideon J Davies, Herman S Overkleeft, Sarel Jacob Fleishman
Combinatorial assembly and design of enzymes. Science (New York, N.Y.) 379 (6628) (2023)
Nicholas G S McGregor, Casper de Boer, Quentin P O Foucart, Thomas J M Beenakker, Wendy A Offen, Jeroen D C Codée, Lianne I Willems, Herman S Overkleeft, Gideon J Davies
A Multiplexing Activity-Based Protein-Profiling Platform for Dissection of a Native Bacterial Xyloglucan-Degrading System. ACS central science 9 (12) (2023)
Yurong Chen, Adrianus M C H van den Nieuwendijk, Liang Wu, Elisha Moran, Foteini Skoulikopoulou, Vera van Riet, Herman S Overkleeft, Gideon J Davies, Zach W B Armstrong
Molecular Basis for Inhibition of Heparanases and β-Glucuronidases by Siastatin B. Journal of the American Chemical Society 146 (1) (2023)
Rosalie Lipsh-Sokolik, Olga Khersonsky, Sybrin P Schröder, Casper de Boer, Shlomo Yakir Hoch, Gideon J Davies, Herman S Overkleeft, Sarel Jacob Fleishman
Combinatorial assembly and design of enzymes. Science (New York, N.Y.) 379 (6628) (2023)
Alexandra Males, Ken Kok, Alba Nin-Hill, Nicky de Koster, Sija van den Beukel, Thomas J M Beenakker, Gijsbert A van der Marel, Jeroen D C Codée, Johannes M F G Aerts, Herman S Overkleeft, Carme Rovira, Gideon J Davies, Marta Artola
Trans -cyclosulfamidate mannose-configured cyclitol allows isoform-dependent inhibition of GH47 α-d-mannosidases through a bump-hole strategy. Chemical science 14 (46) (2023)
Diana Torres-García, Merel A T van de Plassche, Emma van Boven, Tyrza van Leeuwen, Mirjam G J Groenewold, Alexi J C Sarris, Luuk Klein, Herman S Overkleeft, Sander Izaäk van Kasteren
Methyltetrazine as a small live-cell compatible bioorthogonal handle for imaging enzyme activities in situ . RSC chemical biology 3 (11) (2022)
Ken Kok, Chi-Lin Kuo, Rebecca E Katzy, Lindsey T Lelieveld, Liang Wu, Véronique Roig-Zamboni, Gijsbert A van der Marel, Jeroen D C Codée, Gerlind Sulzenbacher, Gideon J Davies, Herman S Overkleeft, Johannes M F G Aerts, Marta Artola
1,6- epi -Cyclophellitol Cyclosulfamidate Is a Bona Fide Lysosomal α-Glucosidase Stabilizer for the Treatment of Pompe Disease. Journal of the American Chemical Society 144 (32) (2022)
Casper de Boer, Zachary Armstrong, Vincent A J Lit, Uri Barash, Gijs Ruijgrok, Ilanit Boyango, Merle M Weitzenberg, Sybrin P Schröder, Alexi J C Sarris, Nico J Meeuwenoord, Pedro Bule, Yasmine Kayal, Neta Ilan, Jeroen D C Codée, Israel Vlodavsky, Herman S Overkleeft, Gideon J Davies, Liang Wu
Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo. Proceedings of the National Academy of Sciences of the United States of America 119 (31) (2022)
Hugo Minnee, Johannes G M Rack, Gijsbert A van der Marel, Herman S Overkleeft, Jeroen D C Codée, Ivan Ahel, Dmitri V Filippov
Mimetics of ADP-Ribosylated Histidine through Copper(I)-Catalyzed Click Chemistry. Organic letters 24 (21) (2022)
Valentina Borlandelli, Zachary Armstrong, Alba Nin-Hill, Jeroen D C Codée, Lluís Raich, Marta Artola, Carme Rovira, Gideon J Davies, Herman S Overkleeft
4-O-Substituted Glucuronic Cyclophellitols are Selective Mechanism-Based Heparanase Inhibitors. ChemMedChem (2022)
Nicholas G S McGregor, Chi-Lin Kuo, Thomas J M Beenakker, Chun-Sing Wong, Wendy A Offen, Zach W B Armstrong, Bogdan I Florea, Jeroen D C Codée, Herman S Overkleeft, Johannes M F G Aerts, Gideon J Davies
Synthesis of broad-specificity activity-based probes for exo -β-mannosidases. Organic & biomolecular chemistry 20 (4) (2022)
Qin Su, Sybrin P Schröder, Lindsey T Lelieveld, Maria J Ferraz, Marri Verhoek, Rolf G Boot, Herman S Overkleeft, Johannes M F G Aerts, Marta Artola, Chi-Lin Kuo
Xylose-Configured Cyclophellitols as Selective Inhibitors for Glucocerebrosidase. Chembiochem : a European journal of chemical biology 22 (21) (2021)
Sybrin P Schröder, Wendy A Offen, Alexandra Males, Yi Jin, Casper de Boer, Jacopo Enotarpi, Laura Marino, Gijsbert A van der Marel, Bogdan I Florea, Jeroen D C Codée, Herman S Overkleeft, Gideon J Davies
Development of Non-Hydrolysable Oligosaccharide Activity-Based Inactivators for Endoglycanases: A Case Study on α-1,6 Mannanases. Chemistry (Weinheim an der Bergstrasse, Germany) 27 (37) (2021)
Vladyslav V Bakhonsky, Aleksander A Pashenko, Jonathan Becker, Heike Hausmann, Huub J M de Groot, Herman S Overkleeft, Andrey A Fokin, Peter Richard Schreiner
Synthesis and antiproliferative activity of hindered, chiral 1,2-diaminodiamantane platinum(II) complexes. Dalton transactions (Cambridge, England : 2003) 49 (40) (2021)
Qiang Liu, Gunnar Knobloch, Jim Voorneveld, Nico J Meeuwenoord, Herman S Overkleeft, Gijsbert A van der Marel, Andreas G Ladurner, Dmitri V Filippov
Chemical synthesis of linear ADP-ribose oligomers up to pentamer and their binding to the oncogenic helicase ALC1. Chemical science 12 (37) (2021)
Manuel Scherer, Andrés G Santana, Kyle Robinson, Steven Zhou, Herman S Overkleeft, Lorne Clarke, Stephen G Withers
Lipid-mimicking phosphorus-based glycosidase inactivators as pharmacological chaperones for the treatment of Gaucher's disease. Chemical science 12 (41) (2021)
Josep Rayo, Rachel Gregor, Nicholas T Jacob, Rambabu Dandela, Luba Dubinsky, Alex Yashkin, Alexander Aranovich, Manikandan Thangaraj, Orna Ernst, Eran Barash, Sergey Malitsky, Bogdan I Florea, Bastiaan P Krom, Erik A C Wiemer, Valerie A Kickhoefer, Leonard H Rome, John C Mathison, Gunnar F Kaufmann, Herman S Overkleeft, Benjamin F Cravatt, Tsaffrir Zor, Kim D Janda, Richard J Ulevitch, Vladimir V Kravchenko, Michael M Meijler
Immunoediting role for major vault protein in apoptotic signaling induced by bacterial N-acyl homoserine lactones. Proceedings of the National Academy of Sciences of the United States of America 118 (12) (2021)
Yurong Chen, Zach W B Armstrong, Marta Artola, Bogdan I Florea, Chi-Lin Kuo, Casper de Boer, Mikkel S Rasmussen, Maher Abou Hachem, Gijsbert A van der Marel, Jeroen D C Codée, Johannes M F G Aerts, Gideon J Davies, Herman S Overkleeft
Activity-Based Protein Profiling of Retaining α-Amylases in Complex Biological Samples. Journal of the American Chemical Society 143 (5) (2021)
Tim P Ofman, Florian Küllmer, Gijsbert A van der Marel, Jeroen D C Codée, Herman S Overkleeft
An Orthogonally Protected Cyclitol for the Construction of Nigerose- and Dextran-Mimetic Cyclophellitols. Organic letters (2021)
Rhianna J Rowland, Yurong Chen, Imogen Breen, Liang Wu, Wendy A Offen, Thomas J Beenakker, Qin Su, Adrianus M C H van den Nieuwendijk, Johannes M F G Aerts, Marta Artola, Herman S Overkleeft, Gideon J Davies
Design, Synthesis and Structural Analysis of Glucocerebrosidase Imaging Agents. Chemistry (Weinheim an der Bergstrasse, Germany) 27 (66) (2021)
Nicholas G S McGregor, Joan Coines, Valentina Borlandelli, Satoko Amaki, Marta Artola, Alba Nin-Hill, Daniël Linzel, Chihaya Yamada, Takatoshi Arakawa, Akihiro Ishiwata, Yukishige Ito, Gijsbert A van der Marel, Jeroen D C Codée, Shinya Fushinobu, Herman S Overkleeft, Carme Rovira, Gideon J Davies
Cysteine Nucleophiles in Glycosidase Catalysis: Application of a Covalent β-l-Arabinofuranosidase Inhibitor. Angewandte Chemie (International ed. in English) 60 (11) (2021)
Niels R M Reintjens, Elena Tondini, Christopher Vis, Toroa McGlinn, Nico J Meeuwenoord, Tim P Hogervorst, Herman S Overkleeft, Dmitri V Filippov, Gijsbert A van der Marel, Ferry Ossendorp, Jeroen D C Codée
Multivalent, Stabilized Mannose-6-Phosphates for the Targeted Delivery of Toll-Like Receptor Ligands and Peptide Antigens. Chembiochem : a European journal of chemical biology 22 (2) (2020)
Xiaohang Qiao, Sabina Y van der Zanden, Dennis P A Wander, Daniel M Borràs, Ji-Ying Song, Xiaoyang Li, Suzanne van Duikeren, Noortje van Gils, Arjo Rutten, Tessa van Herwaarden, Olaf van Tellingen, Elisa Giacomelli, Milena Bellin, Valeria Orlova, Leon G J Tertoolen, Sophie Gerhardt, Jimmy J Akkermans, Jeroen M Bakker, Charlotte L Zuur, Baoxu Pang, Anke M Smits, Christine L Mummery, Linda Smit, Ramon Arens, Junmin Li, Herman S Overkleeft, Jacques Neefjes
Uncoupling DNA damage from chromatin damage to detoxify doxorubicin. Proceedings of the National Academy of Sciences of the United States of America 117 (26) (2020)
Tim P Hogervorst, R J Eveline Li, Laura Marino, Sven C M Bruijns, Nico J Meeuwenoord, Dmitri V Filippov, Herman S Overkleeft, Gijsbert A van der Marel, Sandra J van Vliet, Yvette van Kooyk, Jeroen D C Codée
C-Mannosyl Lysine for Solid Phase Assembly of Mannosylated Peptide Conjugate Cancer Vaccines. ACS chemical biology 15 (3) (2020)
Fredj Ben Bdira, Christopher A Waudby, Alexander N Volkov, Sybrin P Schröder, Eiso Ab, Jeroen D C Codée, Herman S Overkleeft, Johannes M F G Aerts, Hugo van Ingen, Marcellus Ubbink
Dynamics of Ligand Binding to a Rigid Glycosidase*. Angewandte Chemie (International ed. in English) 59 (46) (2020)
Mark A R de Geus, Elmer Maurits, Alexi J C Sarris, Thomas Hansen, Max S Kloet, Kiki Kamphorst, Wolter Ten Hoeve, Marc S Robillard, Andrea Pannwitz, Sylvestre A Bonnet, Jeroen D C Codée, Dmitri V Filippov, Herman S Overkleeft, Sander Izaäk van Kasteren
Fluorogenic Bifunctional trans-Cyclooctenes as Efficient Tools for Investigating Click-to-Release Kinetics. Chemistry (Weinheim an der Bergstrasse, Germany) 26 (44) (2020)
Niels R M Reintjens, Elena Tondini, Ana R de Jong, Nico J Meeuwenoord, Fabrizio Chiodo, Evert Peterse, Herman S Overkleeft, Dmitri V Filippov, Gijsbert A van der Marel, Ferry Ossendorp, Jeroen D C Codée
Self-Adjuvanting Cancer Vaccines from Conjugation-Ready Lipid A Analogues and Synthetic Long Peptides. Journal of medicinal chemistry 63 (20) (2020)
Yvette M C A Luijkx, Nancy M C Bleumink, Jianbing Jiang, Herman S Overkleeft, Marc M S M Wösten, Karin Strijbis, Tom Wennekes
Bacteroides fragilis fucosidases facilitate growth and invasion of Campylobacter jejuni in the presence of mucins. Cellular microbiology 22 (12) (2020)
Zach W B Armstrong, Chi-Lin Kuo, Daniël Lahav, Bing Liu, Rachel Johnson, Thomas J M Beenakker, Casper de Boer, Chung-Sing Wong, Erwin R van Rijssel, Marjoke F Debets, Bogdan I Florea, Colin Hissink, Rolf G Boot, Paul P Geurink, Huib Ovaa, Mario van der Stelt, Jeroen D C Codée, Jeroen D C Codée, Johannes M F G Aerts, Liang Wu, Herman S Overkleeft, Gideon J Davies
Manno-epi-cyclophellitols Enable Activity-Based Protein Profiling of Human α-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors. Journal of the American Chemical Society 142 (30) (2020)
Sascha Hoogendoorn, Gijs H M van Puijvelde, Gijsbert A van der Marel, Chris J van Koppen, C Marco Timmers, Herman S Overkleeft
Fluorescent small-molecule agonists as follicle-stimulating hormone receptor imaging tools. RSC chemical biology 1 (4) (2020)
Nicholas G S McGregor, Marta Artola, Alba Nin-Hill, Daniël Linzel, Mireille Haon, Jos Reijngoud, Arthur Ram, Marie-Noëlle Rosso, Gijsbert A van der Marel, Jeroen D C Codée, Gilles P van Wezel, Jean-Guy Berrin, Carme Rovira, Herman S Overkleeft, Gideon J Davies
Rational Design of Mechanism-Based Inhibitors and Activity-Based Probes for the Identification of Retaining α-l-Arabinofuranosidases. Journal of the American Chemical Society 142 (10) (2020)
Sebastiaan T A Koenders, Eva J van Rooden, Hans van den Elst, Bogdan I Florea, Herman S Overkleeft, Mario van der Stelt
STA-55, an Easily Accessible, Broad-Spectrum, Activity-Based Aldehyde Dehydrogenase Probe. Chembiochem : a European journal of chemical biology 21 (13) (2020)
Elmer Maurits, Michel J van de Graaff, Santina Maiorana, Dennis P A Wander, Patrick M Dekker, Sabina Y van der Zanden, Bogdan I Florea, Jacques J C Neefjes, Herman S Overkleeft, Sander Izaäk van Kasteren
Immunoproteasome Inhibitor-Doxorubicin Conjugates Target Multiple Myeloma Cells and Release Doxorubicin upon Low-Dose Photon Irradiation. Journal of the American Chemical Society 142 (16) (2020)
Casper de Boer, Nicholas G S McGregor, Evert Peterse, Sybrin P Schröder, Bogdan I Florea, Jianbing Jiang, Jos Reijngoud, Arthur F J Ram, Gilles P van Wezel, Gijsbert A van der Marel, Jeroen D C Codée, Herman S Overkleeft, Gideon J Davies
Glycosylated cyclophellitol-derived activity-based probes and inhibitors for cellulases. RSC chemical biology 1 (3) (2020)
Liming Wang, Yongzhen Zhang, Herman S Overkleeft, Gijsbert A van der Marel, Jeroen D C Codée
Reagent Controlled Glycosylations for the Assembly of Well-Defined Pel Oligosaccharides. The Journal of organic chemistry 85 (24) (2020)
Dennis P A Wander, Sabina Y van der Zanden, Gijsbert A van der Marel, Herman S Overkleeft, Jacques J C Neefjes, Jeroen D C Codée
Doxorubicin and Aclarubicin: Shuffling Anthracycline Glycans for Improved Anticancer Agents. Journal of medicinal chemistry 63 (21) (2020)
Nicholas G S McGregor, Johan P Turkenburg, Kristian B R Mørkeberg Krogh, Jens Erik Nielsen, Marta Artola, Keith A Stubbs, Herman S Overkleeft, Gideon J Davies
Structure of a GH51 α-L-arabinofuranosidase from Meripilus giganteus: conserved substrate recognition from bacteria to fungi. Acta crystallographica. Section D, Structural biology 76 (Pt 11) (2020)
Stefan van der Vorm, Thomas Hansen, Erwin R van Rijssel, Rolf Dekkers, Jerre M Madern, Herman S Overkleeft, Dmitri V Filippov, Gijsbert A van der Marel, Jeroen D C Codée
Furanosyl Oxocarbenium Ion Conformational Energy Landscape Maps as a Tool to Study the Glycosylation Stereoselectivity of 2-Azidofuranoses, 2-Fluorofuranoses and Methyl Furanosyl Uronates. Chemistry (Weinheim an der Bergstrasse, Germany) 25 (29) (2019)
Bo-Tao Xin, Eva M Huber, Gerjan de Bruin, Wolfgang Heinemeyer, Elmer Maurits, Christofer Espinal, Yimeng Du, Marissa Janssens, Emily S Weyburne, Alexei F Kisselev, Bogdan I Florea, Christoph Driessen, Gijsbert A van der Marel, Michael Groll, Herman S Overkleeft
Structure-Based Design of Inhibitors Selective for Human Proteasome β2c or β2i Subunits. Journal of medicinal chemistry 62 (3) (2019)
Gijs G Zom, Marian M J H P Willems, Nico J Meeuwenoord, Niels R M Reintjens, Elena Tondini, Selina Khan, Herman S Overkleeft, Gijsbert A van der Marel, Jeroen D C Codée, Ferry Ossendorp, Dmitri V Filippov
Dual Synthetic Peptide Conjugate Vaccine Simultaneously Triggers TLR2 and NOD2 and Activates Human Dendritic Cells. Bioconjugate chemistry 30 (4) (2019)
Arnout Mieremet, Walter A Boiten, Rianne van Dijk, Gert Gooris, Herman S Overkleeft, Johannes M F G Aerts, Joke A Bouwstra, Abdoelwaheb El Ghalbzouri
Unravelling effects of relative humidity on lipid barrier formation in human skin equivalents. Archives of dermatological research 311 (9) (2019)
Sondra Downey-Kopyscinski, Ellen W Daily, Marc Gautier, Ananta Bhatt, Bogdan I Florea, Constantine S Mitsiades, Paul G Richardson, Christoph Driessen, Herman S Overkleeft, Alexei F Kisselev
An inhibitor of proteasome β2 sites sensitizes myeloma cells to immunoproteasome inhibitors. Blood advances 2 (19) (2019)
Marta Artola, Chi-Lin Kuo, Lindsey T Lelieveld, Rhianna J Rowland, Gijsbert A van der Marel, Jeroen D C Codée, Rolf G Boot, Gideon J Davies, Johannes M F G Aerts, Herman S Overkleeft
Functionalized Cyclophellitols Are Selective Glucocerebrosidase Inhibitors and Induce a Bona Fide Neuropathic Gaucher Model in Zebrafish. Journal of the American Chemical Society 141 (10) (2019)
Marta Artola, Shirley Wouters, Sybrin P Schröder, Casper de Boer, Yurong Chen, Rita Petracca, Adrianus M C H van den Nieuwendijk, Johannes M F G Aerts, Gijsbert A van der Marel, Jeroen D C Codée, Herman S Overkleeft
Direct Stereoselective Aziridination of Cyclohexenols with 3-Amino-2-(trifluoromethyl)quinazolin-4(3H)-one in the Synthesis of Cyclitol Aziridine Glycosidase Inhibitors. European journal of organic chemistry 2019 (6) (2019)
Bo-Tao Xin, Christofer Espinal, Gerjan de Bruin, Dmitri V Filippov, Gijsbert A van der Marel, Bogdan I Florea, Herman S Overkleeft
Two-Step Bioorthogonal Activity-Based Protein Profiling of Individual Human Proteasome Catalytic Sites. Chembiochem : a European journal of chemical biology 21 (1-2) (2019)
Anouk M F van der Gracht, Mark A R de Geus, Marcel G M Camps, Tracy J Ruckwardt, Alexi J C Sarris, Jessica Bremmers, Elmer Maurits, Joanna B Pawlak, Michelle M Posthoorn, Kimberly M Bonger, Dmitri V Filippov, Herman S Overkleeft, Marc S Robillard, Ferry Ossendorp, Sander Izaäk van Kasteren
Chemical Control over T-Cell Activation in Vivo Using Deprotection of trans-Cyclooctene-Modified Epitopes. ACS chemical biology 13 (6) (2018)
Liming Wang, Herman S Overkleeft, Gijsbert A van der Marel, Jeroen D C Codée
Reagent Controlled Stereoselective Synthesis of α-Glucans. Journal of the American Chemical Society 140 (13) (2018)
Sybrin P Schröder, Wouter W Kallemeijn, Marjoke F Debets, Thomas Hansen, Lukasz F Sobala, Zalihe Hakki, Spencer J Williams, Thomas J M Beenakker, Johannes M F G Aerts, Gijsbert A van der Marel, Jeroen D C Codée, Gideon J Davies, Herman S Overkleeft
Spiro-epoxyglycosides as Activity-Based Probes for Glycoside Hydrolase Family 99 Endomannosidase/Endomannanase. Chemistry (Weinheim an der Bergstrasse, Germany) 24 (39) (2018)
Sybrin P Schröder, Liang Wu, Marta Artola, Thomas Hansen, Wendy A Offen, Maria J Ferraz, Kah-Yee Li, Johannes M F G Aerts, Gijsbert A van der Marel, Jeroen D C Codée, Gideon J Davies, Herman S Overkleeft
Gluco-1 H-imidazole: A New Class of Azole-Type β-Glucosidase Inhibitor. Journal of the American Chemical Society 140 (15) (2018)
Stefan van der Vorm, Jacob M A van Hengst, Marloes Bakker, Herman S Overkleeft, Gijsbert A van der Marel, Jeroen D C Codée
Mapping the Relationship between Glycosyl Acceptor Reactivity and Glycosylation Stereoselectivity. Angewandte Chemie (International ed. in English) 57 (27) (2018)
Marta Artola, Chi-Lin Kuo, Stephen A McMahon, Verena Oehler, Thomas Hansen, Martijn van der Lienden, Xu He, Hans van den Elst, Bogdan I Florea, Allison R Kermode, Gijsbert A van der Marel, Tracey M Gloster, Jeroen D C Codée, Herman S Overkleeft, Johannes M F G Aerts
New Irreversible α-l-Iduronidase Inhibitors and Activity-Based Probes. Chemistry (Weinheim an der Bergstrasse, Germany) 24 (71) (2018)
Annelot C M van Esbroeck, Antonius P A Janssen, Armand B Cognetta, Daisuke Ogasawara, Guy Shpak, Mark van der Kroeg, Vasudev Kantae, Marc P Baggelaar, Femke M S de Vrij, Hui Deng, Marco Allarà, Filomena Fezza, Zhanmin Lin, Tom van der Wel, Marjolein Soethoudt, Elliot D Mock, Hans den Dulk, Ilse L Baak, Bogdan I Florea, Giel Hendriks, Luciano De Petrocellis, Herman S Overkleeft, Thomas Hankemeier, Chris I De Zeeuw, Vincenzo Di Marzo, Mauro Maccarrone, Benjamin F Cravatt, Steven A Kushner, Mario van der Stelt
Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474. Science (New York, N.Y.) 356 (6342) (2018)
Fredj Ben Bdira, Marta Artola, Herman S Overkleeft, Marcellus Ubbink, Johannes M F G Aerts
Distinguishing the differences in β-glycosylceramidase folds, dynamics, and actions informs therapeutic uses. Journal of lipid research 59 (12) (2018)
Jim Voorneveld, Johannes G M Rack, Ivan Ahel, Herman S Overkleeft, Gijsbert A van der Marel, Dmitri V Filippov
Synthetic α- and β-Ser-ADP-ribosylated Peptides Reveal α-Ser-ADPr as the Native Epimer. Organic letters 20 (13) (2018)
Bas Hagen, J Hessel M van Dijk, Qingju Zhang, Herman S Overkleeft, Gijsbert A van der Marel, Jeroen D C Codée
Synthesis of the Staphylococcus aureus Strain M Capsular Polysaccharide Repeating Unit. Organic letters 19 (10) (2017)
Thomas J M Beenakker, Dennis P A Wander, Wendy A Offen, Marta Artola, Lluís Raich, Maria J Ferraz, Kah-Yee Li, Judith H P M Houben, Erwin R van Rijssel, Thomas Hansen, Gijsbert A van der Marel, Jeroen D C Codée, Johannes M F G Aerts, Carme Rovira, Gideon J Davies, Herman S Overkleeft
Carba-cyclophellitols Are Neutral Retaining-Glucosidase Inhibitors. Journal of the American Chemical Society 139 (19) (2017)
Anne Geert Volbeda, Jeanine van Mechelen, Nico Meeuwenoord, Herman S Overkleeft, Gijsbert A van der Marel, Jeroen D C Codée
Cyanopivaloyl Ester in the Automated Solid-Phase Synthesis of Oligorhamnans. The Journal of organic chemistry 82 (24) (2017)
Fredj Ben Bdira, Wouter W Kallemeijn, Saskia V Oussoren, Saskia Scheij, Boris Bleijlevens, Bogdan I Florea, Cindy P A A van Roomen, Roelof Ottenhoff, Marielle J F M van Kooten, Marthe T C Walvoort, Martin D Witte, Rolf G Boot, Marcellus Ubbink, Herman S Overkleeft, Johannes M F G Aerts
Stabilization of Glucocerebrosidase by Active Site Occupancy. ACS chemical biology 12 (7) (2017)
Jacob Gubbens, Changsheng Wu, Hua Zhu, Dmitri V Filippov, Bogdan I Florea, Sébastien Rigali, Herman S Overkleeft, Gilles P van Wezel
Intertwined Precursor Supply during Biosynthesis of the Catecholate-Hydroxamate Siderophores Qinichelins in Streptomyces sp. MBT76. ACS chemical biology 12 (11) (2017)
Jeroen van Smeden, Irini M Dijkhoff, Richard W J Helder, Hanin Al-Khakany, Daphne E C Boer, Anne Schreuder, Wouter W Kallemeijn, Samira Absalah, Herman S Overkleeft, Johannes M F G Aerts, Joke A Bouwstra
In situ visualization of glucocerebrosidase in human skin tissue: zymography versus activity-based probe labeling. Journal of lipid research 58 (12) (2017)
Daniël Lahav, Bing Liu, Richard J B H N van den Berg, Adrianus M C H van den Nieuwendijk, Tom Wennekes, Amar T Ghisaidoobe, Imogen Breen, Maria J Ferraz, Chi-Lin Kuo, Liang Wu, Paul P Geurink, Huib Ovaa, Gijsbert A van der Marel, Mario van der Stelt, Rolf G Boot, Gideon J Davies, Johannes M F G Aerts, Herman S Overkleeft
A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase. Journal of the American Chemical Society 139 (40) (2017)