N-myc downstream-regulated gene 1 inhibits the proliferation of colorectal cancer through emulative antagonizing NEDD4-mediated ubiquitylation of p21.

Sen ZhangChaoran YuXiao YangHiju HongJiaoyang LuWenjun HuXiaohui HaoShuchun LiBatuer AikemuGuang YangZirui HeLuyang ZhangPei XueZhenghao CaiJunjun MaLu ZangBo FengFei YuanJing SunMinhua Zheng

Published in: Journal of experimental & clinical cancer research : CR (2019)

Our study could fulfill potential mechanisms of the NDRG1 during tumorigenesis and metastasis, which may serve as a tumor suppressor and potential target for new therapies in human colorectal cancer.

Keyphrases

endothelial cells
transcription factor
signaling pathway
human health
copy number
gene expression
dna methylation
pluripotent stem cells