Downregulation of Grem1 expression in the distal limb mesoderm is a necessary precondition for phalanx development.

Joseph J LancmanSean M HassoTakayuki SuzukiYacine KherdjemilMarie KmitaAndrea FerrisP Duc S DongMarian A RosJohn F Fallon

Published in: Developmental dynamics : an official publication of the American Association of Anatomists (2021)

Based on expression and fate mapping studies, we propose that downregulation of Grem1 in the distal limb marks the transition from metatarsal to phalanx development. This suggests that downregulation of Grem1 in the distal limb mesoderm is necessary for phalanx development. Grem1 downregulation allows for full PFR activity and phalanx progenitor cell commitment to digit fate.

Keyphrases

cell proliferation
signaling pathway
poor prognosis
minimally invasive
high resolution
long non coding rna
case control