DNA methylation regulates TIGIT expression within the melanoma microenvironment, is prognostic for overall survival, and predicts progression-free survival in patients treated with anti-PD-1 immunotherapy.

Dennis NiebelAnne FröhlichRomina ZarblSimon FietzLuka de VosTimo J VogtJörn DietrichJudith SirokayPia KusterGonzalo SaavedraSusana Ramírez ValladolidFriederike HoffmannSebastian StriethJennifer LandsbergDimo Dietrich

Published in: Clinical epigenetics (2022)

Our data demonstrate an epigenetic regulation of TIGIT expression via DNA methylation within the melanoma microenvironment. TIGIT DNA methylation and expression may serve as predictive biomarkers in the context of immunotherapies in melanoma.

Keyphrases

dna methylation
poor prognosis
free survival
genome wide
gene expression
stem cells
long non coding rna
machine learning
deep learning
big data
artificial intelligence