Pharmacokinetics and Optimal Dosing of Levofloxacin in Children for Drug-Resistant Tuberculosis: An Individual Patient Data Meta-Analysis.
Yasmine N WhiteBelen P SolansPaolo DentiLouvina E van der LaanH Simon SchaafBryan VonasekAmyn A MalikHeather R DraperHamidah HussainAnneke C HesselingAnthony J Garcia-PratsRadojka M SavicPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2024)
Revised weight-band dosing guidelines with doses of >20 mg/kg are required to ensure adequate exposure. Further studies are needed to determine safety and tolerability of these higher doses.
Keyphrases
- drug resistant
- systematic review
- case control
- multidrug resistant
- acinetobacter baumannii
- mycobacterium tuberculosis
- meta analyses
- young adults
- open label
- electronic health record
- body mass index
- case report
- weight loss
- physical activity
- clinical practice
- weight gain
- big data
- hiv aids
- randomized controlled trial
- clinical trial
- machine learning
- double blind
- pseudomonas aeruginosa
- body weight
- placebo controlled
- cystic fibrosis