Should Ultrasound-Guided High Frequency Focused Ultrasound Be Considered as an Alternative Non-Surgical Treatment of Uterine Fibroids in Non-Asiatic Countries? An Opinion Paper.
Luz Angela Torres-de la RocheSarah RafiqRajesh DevassyHugo Christian VerhoevenSven BeckerRudy Leon De WildePublished in: Journal of clinical medicine (2022)
Minimally invasive interventions for myomata treatment have gained acceptance due to the possibility of preserving fertility with reduced trauma induced by laparotomy as way of entrance. There are insufficient data regarding outcomes of high intensity focused ultrasound (HIFU) in non-Asiatic women. Therefore, we revised the available evidence to present an expert opinion that could support physicians, patients and policy-makers for considering this approach in other populations. We revisited systematic reviews, randomized controlled trials and cohort studies from January 2018 to August 2021 using PubMed and Google scholar, regarding short and long term outcomes after ablation with focused ultrasound waves. In total, 33 studies, including 114,810 adult patients showed that outcomes of this approach depend on several parameters directly related with resistance to thermal ablation, especially fibroid size and vascularization. Two studies report satisfactory outcomes in Afro-American women. In accordance to the technique used, fibroid volume reduction showed to be higher in fibroids <300 cm 3 after ultrasound guided HIFU than after MRI guided. Compared to myomectomy and uterine artery embolization, HIFU seems to have shorter hospital stay, higher pregnancy rates and similar adverse events rates, with skin burn being the most reported. Symptoms and quality of life improvement is similar to myomectomy but lower than embolization, however reintervention rate is higher after HIFU. Lacks evidence about long-term sarcoma risk after ablation. Available evidence shows that HIFU can be considered as a uterine sparing treatment for women of different ethnicities suffering of uterine myomatosis, especially for those wishing to preserve their fertility.
Keyphrases
- high intensity
- pregnancy outcomes
- high frequency
- ultrasound guided
- resistance training
- polycystic ovary syndrome
- end stage renal disease
- minimally invasive
- randomized controlled trial
- transcranial magnetic stimulation
- systematic review
- healthcare
- chronic kidney disease
- primary care
- magnetic resonance imaging
- public health
- emergency department
- pregnant women
- robot assisted
- metabolic syndrome
- mental health
- radiofrequency ablation
- physical activity
- peritoneal dialysis
- breast cancer risk
- computed tomography
- preterm birth
- machine learning
- case control
- depressive symptoms
- prognostic factors
- electronic health record
- patient reported outcomes
- smoking cessation
- replacement therapy
- patient reported