Hydroxychloroquine induces apoptosis of myeloid-derived suppressor cells via up-regulation of CD81 contributing to alleviate lupus symptoms.

Jiali NiHaiyan ZhuLi LuZihe ZhaoJiaxuan JiangXiaokang YouYuzhu WangYuliang MaZirui YangYayi HouHuan Dou

Published in: Molecular medicine (Cambridge, Mass.) (2022)

In summary, HCQ promoted the apoptosis of MDSCs by up-regulating the expression level of CD81 in MDSCs, and ultimately alleviated lupus symptoms. Our results may assist scholars to develop further effective therapies for SLE.

Keyphrases

systemic lupus erythematosus
cell cycle arrest
disease activity
induced apoptosis
endoplasmic reticulum stress
cell death
poor prognosis
oxidative stress
rheumatoid arthritis
sleep quality
nk cells
binding protein
physical activity
long non coding rna