The Use of Efavirenz During Pregnancy is Associated with Suicidal Ideation in Postpartum Women in Rural South Africa.
Deborah L JonesVioleta J RodriguezMaria L AlcaideStephen M WeissKarl PeltzerPublished in: AIDS and behavior (2019)
Efavirenz is used for the management of HIV infection during pregnancy in South Africa (SA), but it is contraindicated in patients with history of depression due to possible suicidal ideation. This study compared suicidal ideation 12-months postpartum among women receiving and not receiving efavirenz in rural SA, where high rates of depression have been identified. Antenatal psychological intimate partner violence (IPV; AOR = 1.04), depression (AOR = 1.06) and detection of efavirenz in dried blood spot at 32 weeks predicted suicidal ideation 12-months postnatally (AOR = 2.29), controlling for antenatal stigma and physical IPV. Findings support using alternative agents for the management of HIV during pregnancy.
Keyphrases
- antiretroviral therapy
- south africa
- intimate partner violence
- hiv positive
- hiv infected
- hiv aids
- hiv infected patients
- human immunodeficiency virus
- sleep quality
- depressive symptoms
- pregnant women
- polycystic ovary syndrome
- mental health
- pregnancy outcomes
- physical activity
- preterm birth
- type diabetes
- social support
- cervical cancer screening
- mental illness
- skeletal muscle
- men who have sex with men
- hepatitis c virus
- adipose tissue
- label free
- hiv testing
- loop mediated isothermal amplification