Airway Deposition of Extrafine Inhaled Triple Therapy in Patients with COPD: A Model Approach Based on Functional Respiratory Imaging Computer Simulations.

Omar S Usmani Nicola ScichiloneBenjamin MignotDennis BelmansCedric Van HolsbekeJan De BackerRoberta De MariaErika CuoghiEva TopoleGeorge Georges

Published in: International journal of chronic obstructive pulmonary disease (2020)

Peripheral (small airways) deposition of all three components (ICS, LABA, and LAMA) was higher from BDP/FF/GB than from FluF/VI/UMEC, based on profiles from patients with moderate to very severe COPD. This is consistent with the extrafine formulation of BDP/FF/GB.

Keyphrases

chronic obstructive pulmonary disease
lung function
cystic fibrosis
high resolution
drug delivery
deep learning
early onset
high intensity
molecular dynamics
muscular dystrophy
air pollution
mass spectrometry
drug induced
fluorescence imaging
photodynamic therapy
cell therapy