Nicola Scichilone (N Scichilone)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 52

Top Topics

Chronic Obstructive Pulmonary Disease

Rheumatoid Arthritis Patients

Top Venues

Journal of clinical medicine

ERJ open research

International journal of chronic obstructive pulmonary disease

This page only lists publications with an associated author ORCID identifier.

Publications

Pierachille Santus, Federico Raimondi, Matteo Bonini, Marco Contoli, Angelo Guido Corsico, Claudio Micheletto, Girolamo Pelaia, Dejan Radovanovic, Rogliani Paola, Laura Saderi, Nicola Scichilone, Silvia Tanzi, Manlio Vella, Silvia Boarino, Giovanni Sotgiu, Paolo Solidoro
Exacerbation Burden in COPD and Occurrence of Mortality in a Cohort of Italian Patients: Results of the Gulp Study. International journal of chronic obstructive pulmonary disease 19 (2024)
Giuseppe Zinna, Luca Pipitò, Claudia Colomba, Nicola Scichilone, Anna Licata, Mario Barbagallo, Antonio Russo, Piero Luigi Almasio, Nicola Coppola, Antonio Cascio
COVID-19: The Development and Validation of a New Mortality Risk Score. Journal of clinical medicine 13 (7) (2024)
Giuseppe Zinna, Luca Pipitò, Claudia Colomba, Nicola Scichilone, Anna Licata, Mario Barbagallo, Antonio Russo, Piero Luigi Almasio, Nicola Coppola, Antonio Cascio
COVID-19: The Development and Validation of a New Mortality Risk Score. Journal of clinical medicine 13 (7) (2024)
Carlo Chessari, Edoardo Simonetta, Francesco Amati, Mattia Nigro, Anna Stainer, Giovanni Sotgiu, Mariangela Puci, Andrea Gramegna, Francesco Blasi, Letizia Corinna Morlacchi, Agata Alba Maria Domenica Buscemi, Valentina Conio, Vincenzo Sanci, Angelo G Corsico, Paola Faverio, Weronika Michalak, Fabrizio Luppi, Claudia Crimi, Carlo Vancheri, Raffaele Campisi, Maria Rosaria Vulpi, Giovanna Elisiana Carpagnano, Marianna Cicchetti, Kseniia Sekretna, Nicola Scichilone, Salvatore Battaglia, Stefano Aliberti
Diagnostic delay in bronchiectasis: an Italian perspective. ERJ open research 10 (2) (2024)
Corrado Pelaia, Claudia Crimi, Alida Benfante, Maria Filomena Caiaffa, Raffaele Campisi, Claudio Candia, Giovanna Elisiana Carpagnano, Isabella Carrieri, Maria D'Amato, Aikaterini Detoraki, Maria Pia Foschino Barbaro, Nicola Lombardo, Luigi Macchia, Angelantonio Maglio, Elena Minenna, Santi Nolasco, Giuseppe Paglino, Francesco Papia, Luisa Ricciardi, Nicola Scichilone, Giulia Scioscia, Giuseppe Spadaro, Pasquale Tondo, Simona Uletta Lionetti, Giuseppe Valenti, Alessandro Vatrella, Nunzio Crimi, Girolamo Pelaia
Sustained remission induced by 2 years of treatment with benralizumab in patients with severe eosinophilic asthma and nasal polyposis. Respirology (Carlton, Vic.) (2024)
Pierachille Santus, Federico Raimondi, Matteo Bonini, Marco Contoli, Angelo Guido Corsico, Claudio Micheletto, Girolamo Pelaia, Dejan Radovanovic, Rogliani Paola, Laura Saderi, Nicola Scichilone, Silvia Tanzi, Manlio Vella, Silvia Boarino, Giovanni Sotgiu, Paolo Solidoro
Exacerbation Burden in COPD and Occurrence of Mortality in a Cohort of Italian Patients: Results of the Gulp Study. International journal of chronic obstructive pulmonary disease 19 (2024)
Giuseppe Zinna, Luca Pipitò, Claudia Colomba, Nicola Scichilone, Anna Licata, Mario Barbagallo, Antonio Russo, Piero Luigi Almasio, Nicola Coppola, Antonio Cascio
COVID-19: The Development and Validation of a New Mortality Risk Score. Journal of clinical medicine 13 (7) (2024)
Carlo Chessari, Edoardo Simonetta, Francesco Amati, Mattia Nigro, Anna Stainer, Giovanni Sotgiu, Mariangela Puci, Andrea Gramegna, Francesco Blasi, Letizia Corinna Morlacchi, Agata Alba Maria Domenica Buscemi, Valentina Conio, Vincenzo Sanci, Angelo G Corsico, Paola Faverio, Weronika Michalak, Fabrizio Luppi, Claudia Crimi, Carlo Vancheri, Raffaele Campisi, Maria Rosaria Vulpi, Giovanna Elisiana Carpagnano, Marianna Cicchetti, Kseniia Sekretna, Nicola Scichilone, Salvatore Battaglia, Stefano Aliberti
Diagnostic delay in bronchiectasis: an Italian perspective. ERJ open research 10 (2) (2024)
Alessandra Fallucca, Patrizia Ferro, Luca Mazzeo, Luigi Zagra, Elena Cocciola, Roberta Oliveri, Antonino Tuttolomondo, Alida Benfante, Salvatore Battaglia, Nicola Scichilone, Nicola Veronese, Marco Affronti, Mario Barbagallo, Alessandra Casuccio, Francesco Vitale, Vincenzo Restivo, null The Aoup Inpatient Vaccination Team
Impact of Actively Offering Influenza Vaccination to Frail People during Hospitalisation: A Pilot Study in Italy. Vaccines 11 (12) (2023)
Vitaliano Nicola Quaranta, Silvano Dragonieri, Maria Rosaria Vulpi, Nunzio Crimi, Claudia Crimi, Pierachille Santus, Francesco Menzella, Corrado Pelaia, Giulia Scioscia, Cristiano Caruso, Elena Bargagli, Nicola Scichilone, Giovanna Elisiana Carpagnano
High Level of Blood Eosinophils and Localization of Bronchiectasis in Patients with Severe Asthma: A Pilot Study. Journal of clinical medicine 12 (1) (2023)
Vitaliano Nicola Quaranta, Silvano Dragonieri, Maria Rosaria Vulpi, Nunzio Crimi, Claudia Crimi, Pierachille Santus, Francesco Menzella, Corrado Pelaia, Giulia Scioscia, Cristiano Caruso, Elena Bargagli, Nicola Scichilone, Giovanna Elisiana Carpagnano
High Level of Blood Eosinophils and Localization of Bronchiectasis in Patients with Severe Asthma: A Pilot Study. Journal of clinical medicine 12 (1) (2023)
Stefania Principe, Levi B Richards, Simone Hashimoto, Johannes Anthon Kroes, Job J M H Van Bragt, Susanne J Vijverberg, Jacob K Sont, Nicola Scichilone, Kristina Bieksiene, Anneke Ten Brinke, Zsuzsanna Csoma, Barbro Dahlén, Bilun Gemicioglu, Ineta Grisle, Piotr Kuna, Zorica Lazic, Florin Mihaltan, Sanja Popović-Grle, Sabina Škrgat, Alessandro Marcon, Marco Caminati, Ratko Djukanovic, Celeste Porsbjerg, Anke-Hilse Maitland Van Der Zee
Characteristics of severe asthma patients on biologics: a real-life European registry study. ERJ open research 9 (3) (2023)
Alessandra Fallucca, Patrizia Ferro, Luca Mazzeo, Luigi Zagra, Elena Cocciola, Roberta Oliveri, Antonino Tuttolomondo, Alida Benfante, Salvatore Battaglia, Nicola Scichilone, Nicola Veronese, Marco Affronti, Mario Barbagallo, Alessandra Casuccio, Francesco Vitale, Vincenzo Restivo, null The Aoup Inpatient Vaccination Team
Impact of Actively Offering Influenza Vaccination to Frail People during Hospitalisation: A Pilot Study in Italy. Vaccines 11 (12) (2023)
Alida Benfante, Alessandra Tomasello, Enrico Gianquinto, Maria Noemi Cicero, Nicola Scichilone
Diagnostic and therapeutic approaches for elderly asthma patients: the importance of multidisciplinary and multidimensional management. Expert review of respiratory medicine (2023)
Alida Benfante, Alessandra Tomasello, Enrico Gianquinto, Maria Noemi Cicero, Nicola Scichilone
Diagnostic and therapeutic approaches for elderly asthma patients: The importance of multidisciplinary and multidimensional management. Expert review of respiratory medicine (2023)
Stefania Principe, Levi B Richards, Simone Hashimoto, Johannes Anthon Kroes, Job J M H Van Bragt, Susanne J Vijverberg, Jacob K Sont, Nicola Scichilone, Kristina Bieksiene, Anneke Ten Brinke, Zsuzsanna Csoma, Barbro Dahlén, Bilun Gemicioglu, Ineta Grisle, Piotr Kuna, Zorica Lazic, Florin Mihaltan, Sanja Popović-Grle, Sabina Škrgat, Alessandro Marcon, Marco Caminati, Ratko Djukanovic, Celeste Porsbjerg, Anke-Hilse Maitland Van Der Zee
Characteristics of severe asthma patients on biologics: a real-life European registry study. ERJ open research 9 (3) (2023)
Vitaliano Nicola Quaranta, Silvano Dragonieri, Maria Rosaria Vulpi, Nunzio Crimi, Claudia Crimi, Pierachille Santus, Francesco Menzella, Corrado Pelaia, Giulia Scioscia, Cristiano Caruso, Elena Bargagli, Nicola Scichilone, Giovanna Elisiana Carpagnano
High Level of Blood Eosinophils and Localization of Bronchiectasis in Patients with Severe Asthma: A Pilot Study. Journal of clinical medicine 12 (1) (2023)
Raffaele Campisi, Santi Nolasco, Corrado Pelaia, Pietro Impellizzeri, Maria D'Amato, Andrea Portacci, Luisa Ricciardi, Giulia Scioscia, Nunzio Crimi, Nicola Scichilone, Maria Pia Foschino Barbaro, Girolamo Pelaia, Giovanna Elisiana Carpagnano, Alessandro Vatrella, Claudia Crimi, null null
Benralizumab Effectiveness in Severe Eosinophilic Asthma with Co-Presence of Bronchiectasis: A Real-World Multicentre Observational Study. Journal of clinical medicine 12 (12) (2023)
Stefania Principe, Levi B Richards, Simone Hashimoto, Johannes Anthon Kroes, Job J M H Van Bragt, Susanne J Vijverberg, Jacob K Sont, Nicola Scichilone, Kristina Bieksiene, Anneke Ten Brinke, Zsuzsanna Csoma, Barbro Dahlén, Bilun Gemicioglu, Ineta Grisle, Piotr Kuna, Zorica Lazic, Florin Mihaltan, Sanja Popović-Grle, Sabina Škrgat, Alessandro Marcon, Marco Caminati, Ratko Djukanovic, Celeste Porsbjerg, Anke-Hilse Maitland Van Der Zee
Characteristics of severe asthma patients on biologics: a real-life European registry study. ERJ open research 9 (3) (2023)
Raffaele Campisi, Santi Nolasco, Corrado Pelaia, Pietro Impellizzeri, Maria D'Amato, Andrea Portacci, Luisa Ricciardi, Giulia Scioscia, Nunzio Crimi, Nicola Scichilone, Maria Pia Foschino Barbaro, Girolamo Pelaia, Giovanna Elisiana Carpagnano, Alessandro Vatrella, Claudia Crimi, null null
Benralizumab Effectiveness in Severe Eosinophilic Asthma with Co-Presence of Bronchiectasis: A Real-World Multicentre Observational Study. Journal of clinical medicine 12 (12) (2023)
Andrea Portacci, Raffaele Campisi, Enrico Buonamico, Santi Nolasco, Corrado Pelaia, Nunzio Crimi, Alida Benfante, Massimo Triggiani, Giuseppe Spadaro, Maria Filomena Caiaffa, Giulia Scioscia, Aikaterini Detoraki, Giuseppe Valenti, Francesco Papia, Alessandra Tomasello, Nicola Scichilone, Girolamo Pelaia, Claudia Crimi, Giovanna Elisiana Carpagnano
Real-world characteristics of "super-responders" to mepolizumab and benralizumab in severe eosinophilic asthma and eosinophilic granulomatosis with polyangiitis. ERJ open research 9 (5) (2023)
Vitaliano Nicola Quaranta, Silvano Dragonieri, Maria Rosaria Vulpi, Nunzio Crimi, Claudia Crimi, Pierachille Santus, Francesco Menzella, Corrado Pelaia, Giulia Scioscia, Cristiano Caruso, Elena Bargagli, Nicola Scichilone, Giovanna Elisiana Carpagnano
High Level of Blood Eosinophils and Localization of Bronchiectasis in Patients with Severe Asthma: A Pilot Study. Journal of clinical medicine 12 (1) (2023)
Vitaliano Nicola Quaranta, Silvano Dragonieri, Nunzio Crimi, Claudia Crimi, Pierachille Santus, Francesco Menzella, Corrado Pelaia, Giulia Scioscia, Cristiano Caruso, Elena Bargagli, Konstantinos Kostikas, Christos Kyriakopoulos, Nicola Scichilone, Giovanna Elisiana Carpagnano
Can Leukotriene Receptor Antagonist Therapy Improve the Control of Patients with Severe Asthma on Biological Therapy and Coexisting Bronchiectasis? A Pilot Study. Journal of clinical medicine 11 (16) (2022)
Stefania Principe, Amelia Grosso, Alida Benfante, Federica Albicini, Salvatore Battaglia, Erica Gini, Marta Amata, Ilaria Piccionello, Angelo Guido Corsico, Nicola Scichilone
Comparison between Suspected and Confirmed COVID-19 Respiratory Patients: What Is beyond the PCR Test. Journal of clinical medicine 11 (11) (2022)
Marta Di Simone, Anna Maria Corsale, Elena Lo Presti, Nicola Scichilone, Carmela Picone, Lydia Giannitrapani, Francesco Dieli, Serena Meraviglia
Phenotypical and Functional Alteration of γδ T Lymphocytes in COVID-19 Patients: Reversal by Statins. Cells 11 (21) (2022)
Domenico Di Raimondo, Gaia Musiari, Giuliana Rizzo, Edoardo Pirera, Alida Benfante, Salvatore Battaglia, Daniela Colomba, Antonino Tuttolomondo, Nicola Scichilone, Antonio Pinto
Echocardiographic Evaluation of the Cardiac Chambers in Asthmatic Patients: The BADA (Blood Pressure Levels, Clinical Features and Markers of Subclinical Cardiovascular Damage of Asthma Patients) Study-ECO. Journal of personalized medicine 12 (11) (2022)
Domenico Di Raimondo, Gaia Musiari, Giuliana Rizzo, Edoardo Pirera, Alida Benfante, Salvatore Battaglia, Daniela Colomba, Antonino Tuttolomondo, Nicola Scichilone, Antonio Pinto
Echocardiographic Evaluation of the Cardiac Chambers in Asthmatic Patients: The BADA (Blood Pressure Levels, Clinical Features and Markers of Subclinical Cardiovascular Damage of Asthma Patients) Study-ECO. Journal of personalized medicine 12 (11) (2022)
Alida Benfante, Bernardo Sousa-Pinto, Gianluca Pillitteri, Salvatore Battaglia, João Almeida Fonseca, Jean Bousquet, Nicola Scichilone
Applicability of the MASK-Air ® App to Severe Asthma Treated with Biologic Molecules: A Pilot Study. International journal of molecular sciences 23 (19) (2022)
Stefania Principe, Alida Benfante, Salvatore Battaglia, Anke H Maitland Van Der Zee, Nicola Scichilone
The potential role of SP-D as an early biomarker of severity of asthma. Journal of breath research 15 (4) (2021)
Corrado Pelaia, Claudia Crimi, Alida Benfante, Maria Filomena Caiaffa, Cecilia Calabrese, Giovanna Elisiana Carpagnano, Domenico Ciotta, Maria D'Amato, Luigi Macchia, Santi Nolasco, Girolamo Pelaia, Simona Pellegrino, Nicola Scichilone, Giulia Scioscia, Giuseppe Spadaro, Giuseppe Valenti, Alessandro Vatrella, Nunzio Crimi
Therapeutic Effects of Benralizumab Assessed in Patients with Severe Eosinophilic Asthma: Real-Life Evaluation Correlated with Allergic and Non-Allergic Phenotype Expression. Journal of asthma and allergy 14 (2021)
Raffaele Campisi, Claudia Crimi, Santi Nolasco, Bianca Beghè, Leonardo Antonicelli, Gabriella Guarnieri, Nicola Scichilone, Morena Porto, Luigi Macchia, Giulia Scioscia, Maria Pia Foschino Barbaro, Alberto Papi, Nunzio Crimi
Real-World Experience with Dupilumab in Severe Asthma: One-Year Data from an Italian Named Patient Program. Journal of asthma and allergy 14 (2021)
Danilo Di Bona, Claudia Crimi, Angela Maria D'Uggento, Alida Benfante, Maria Filomena Caiaffa, Cecilia Calabrese, Raffaele Campisi, Giovanna Elisiana Carpagnano, Domenico Ciotta, Maria D'Amato, Corrado Pelaia, Girolamo Pelaia, Simona Pellegrino, Nicola Scichilone, Giulia Scioscia, Nunziata Ribecco, Giuseppe Spadaro, Giuseppe Valenti, Alessandro Vatrella, Nunzio Crimi, Luigi Macchia
Effectiveness of benralizumab in severe eosinophilic asthma: Distinct sub-phenotypes of response identified by cluster analysis. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2021)
Francesco Blasi, Raffaele Antonelli Incalzi, Giorgio Walter Canonica, Pietro Schino, Giuseppina Cuttitta, Alessandro Zullo, Alessandra Ori, Nicola Scichilone, null null
Clinical Evolution and Quality of Life in Clinically Based COPD Chronic Bronchitic and Emphysematous Phenotypes: Results from the 1-Year Follow-Up of the STORICO Italian Observational Study. International journal of chronic obstructive pulmonary disease 16 (2021)
Corrado Pelaia, Claudia Crimi, Nunzio Crimi, Luisa Ricciardi, Nicola Scichilone, Giuseppe Valenti, Ornella Bonavita, Stefano Andaloro, Paolo Morini, Andrea Rizzi, Girolamo Pelaia
Indacaterol/Glycopyrronium/Mometasone fixed dose combination for uncontrolled asthma. Expert review of respiratory medicine (2021)
Stefania Principe, Job J M H van Bragt, Cristina Longo, Rianne de Vries, Peter J Sterk, Nicola Scichilone, Susanne J H Vijverberg, Anke H Maitland-van der Zee
The Influence of Smoking Status on Exhaled Breath Profiles in Asthma and COPD Patients. Molecules (Basel, Switzerland) 26 (5) (2021)
Raffaele Antonelli Incalzi, Francesco Blasi, Nicola Scichilone, Alessandro Zullo, Lucia Simoni, Giorgio Walter Canonica, null null
One-Year Evolution of Symptoms and Health Status of the COPD Multi-Dimensional Phenotypes: Results from the Follow-Up of the STORICO Observational Study. International journal of chronic obstructive pulmonary disease 16 (2021)
Job J M H van Bragt, Stefania Principe, Simone Hashimoto, D Naomi Versteeg, Paul Brinkman, Susanne J H Vijverberg, Els J M Weersink, Nicola Scichilone, Anke H Maitland-van der Zee
Exhaled Metabolite Patterns to Identify Recent Asthma Exacerbations. Metabolites 11 (12) (2021)
Pierluigi Paggiaro, Simona Barbaglia, Stefano Centanni, Davide Croce, Enrico Desideri, Saffi Giustini, Claudio Micheletto, Antonino Musarra, Nicola Scichilone, Ugo Trama, Maria Teresa Zedda, Giorgio Walter Canonica
Overcoming Barriers to the Effective Management of Severe Asthma in Italy. Journal of asthma and allergy 14 (2021)
Filippo Patrucco, Alida Benfante, Elisa Villa, Stefania Principe, Nicola Scichilone, Paolo Solidoro
Severe asthma and COVID-19: lessons from the first wave. The Journal of asthma : official journal of the Association for the Care of Asthma (2020)
Nicola Scichilone, Peter John Barnes, Salvatore Battaglia, Alida Benfante, Robert Brown, Giorgio Walter Canonica, Gaetano Caramori, Mario Cazzola, Stefano Centanni, Antonella Cianferoni, Angelo Corsico, Giuseppe De Carlo, Federico Raimondi, Mina Gaga, Catherine Hawrylowicz, Enrico Heffler, Maria Gabriella Matera, Andrea Matucci, Pierluigi Paggiaro, Alberto Papi, Todor A Popov, Rogliani Paola, Pierachille Santus, Paolo Solidoro, Alkis Togias, Louis-Philippe Boulet
The Hidden Burden of Severe Asthma: From Patient Perspective to New Opportunities for Clinicians. Journal of clinical medicine 9 (8) (2020)
Riccardo Messina, Giuliana Guggino, Alida Benfante, Nicola Scichilone
Interstitial Lung Disease in Elderly Rheumatoid Arthritis Patients. Drugs & aging 37 (1) (2020)
Domenico Di Raimondo, Gaia Musiari, Alida Benfante, Salvatore Battaglia, Giuliana Rizzo, Antonino Tuttolomondo, Nicola Scichilone, Antonio Pinto
Prevalence of Arterial Hypertension and Characteristics of Nocturnal Blood Pressure Profile of Asthma Patients According to Therapy and Severity of the Disease: The BADA Study. International journal of environmental research and public health 17 (18) (2020)
Matteo Bonini, Marcello Di Paolo, Diego Bagnasco, Ilaria Baiardini, Fulvio Braido, Marco Caminati, Elisiana Carpagnano, Marco Contoli, Angelo Corsico, Stefano R Del Giacco, Enrico Heffler, Carlo Lombardi, Ilaria Menichini, Manlio Milanese, Nicola Scichilone, Gianenrico Senna, Giorgio W Canonica
Minimal clinically important difference for asthma endpoints: an expert consensus report. European respiratory review : an official journal of the European Respiratory Society 29 (156) (2020)
Nicola Scichilone, Laura Basile, Salvatore Battaglia, Alida Benfante, Roberto Fonte, Francesco Gambino, Stefania Marino, Riccardo Messina, Sonia Poma, Stefania Principe, Giovanni Salamone, Marta Zammuto
Management of suspected COVID-19 patients in a low prevalence region. Chronic respiratory disease 17 (2020)
Omar S Usmani, Nicola Scichilone, Benjamin Mignot, Dennis Belmans, Cedric Van Holsbeke, Jan De Backer, Roberta De Maria, Erika Cuoghi, Eva Topole, George Georges
Airway Deposition of Extrafine Inhaled Triple Therapy in Patients with COPD: A Model Approach Based on Functional Respiratory Imaging Computer Simulations. International journal of chronic obstructive pulmonary disease 15 (2020)
Alberto Braghiroli, Matteo Bonini, Alessio Piraino, Rogliani Paola, Pierachille Santus, Nicola Scichilone
Day and Night Control of COPD and Role of Pharmacotherapy: A Review. International journal of chronic obstructive pulmonary disease 15 (2020)
Salvatore Battaglia, Alida Benfante, Stefania Principe, Laura Basile, Nicola Scichilone
Urinary Incontinence in Chronic Obstructive Pulmonary Disease: A Common Co-morbidity or a Typical Adverse Effect? Drugs & aging 36 (9) (2019)
Nicola Scichilone, Fulvio Braido, Federico Lavorini, Mark L Levy, Omar S Usmani
Routine Use of Budesonide/Formoterol Fixed Dose Combination in Elderly Asthmatic Patients: Practical Considerations. Drugs & aging 34 (5) (2017)
Salvatore Battaglia, Nicola Scichilone
Eligibility of real-life patients with COPD for inclusion in RCTs: a commentary. Respiratory research 18 (1) (2017)
Rita Arrigo, Giuseppe Failla, Nicola Scichilone, Alba La Sala, Carla Galeone, Salvatore Battaglia, Alida Benfante, Nicola Facciolongo
How Effective and Safe Is Bronchial Thermoplasty in "Real Life" Asthmatics Compared to Those Enrolled in Randomized Clinical Trials? BioMed research international 2016 (2016)
Alida Benfante, Nicola Scichilone
The geriatric asthma: pitfalls and challenges. Asthma research and practice 2 (2016)
Nicola Scichilone, C Crimi, A Benfante, S Battaglia, M Iemmolo, M Spatafora, N Crimi
Higher serum levels of periostin and the risk of exacerbations in moderate asthmatics. Asthma research and practice 2 (2016)