CD4+ Cell infiltration into subcutaneous adipose tissue is not indicative of productively infected cells during acute SHIV infection.
Denise C HsuMatthew D WegnerPiyanate SunyakumthornDecha SilsornSujitra TayamunDutsadee InthawongYanin KuncharinRawiwan Im-ErbsinChristine EgeRobert J O'ConnellNelson L MichaelLishomwa C NdhlovuSandhya VasanPublished in: Journal of medical primatology (2018)
Limited longitudinal data exist on the effect of HIV on adipose tissue (AT). We found an increase in CD4+ cells and detectable SHIV-RNA in AT during acute SHIV infection. SHIV-RNA+ cells were rare, suggesting that AT is unlikely to be a major source of productively infected cells in SHIV infection.