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Toxin inhibition: Examining tetracyclines, clindamycin, and linezolid.

Sarah B GreenBenjamin AlbrechtRyan ChapinJillian Walters
Published in: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists (2024)
Toxin inhibition plays a key role in successful management of patients with infections due to toxin-producing organisms. Adjunctive therapy with a tetracycline could be considered in severe, fulminant CDI, but the associated benefit is variable. The benefit of antitoxin treatment for necrotizing S. aureus and S. pyogenes has been more consistently documented. Recent studies support linezolid as an alternative to clindamycin as an adjunctive S. aureus treatment or as monotherapy when appropriate.
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