DNA methylation changes and inflammaging in aging-associated diseases.
Mina AlimohammadiShima MakaremiAli RahimiVahid AsghariazarMahdi TaghadosiElham SafarzadehPublished in: Epigenomics (2022)
Aging as an inevitable phenomenon is associated with pervasive changes in physiological functions. There is a relationship between aging and the increase of several chronic diseases. Most age-related disorders are accompanied by an underlying chronic inflammatory state, as demonstrated by local infiltration of inflammatory cells and greater levels of proinflammatory cytokines in the bloodstream. Within inflammaging, many epigenetic events, especially DNA methylation, change. During the aging process, due to aberrations of DNA methylation, biological processes are disrupted, leading to the emergence or progression of a variety of human diseases, including cancer, neurodegenerative disorders, cardiovascular disease and diabetes. The focus of this review is on DNA methylation, which is involved in inflammaging-related activities, and how its dysregulation leads to human disorders.
Keyphrases
- dna methylation
- cardiovascular disease
- genome wide
- gene expression
- endothelial cells
- type diabetes
- induced apoptosis
- induced pluripotent stem cells
- oxidative stress
- pluripotent stem cells
- papillary thyroid
- escherichia coli
- cell cycle arrest
- glycemic control
- squamous cell carcinoma
- young adults
- adipose tissue
- insulin resistance
- metabolic syndrome
- drug induced
- coronary artery disease
- gram negative
- squamous cell
- functional connectivity
- multidrug resistant