Isobavachalcone Induces ROS-Mediated Apoptosis via Targeting Thioredoxin Reductase 1 in Human Prostate Cancer PC-3 Cells.
Kai LiQiu-Sheng ZhengXiaoyu ChenYunchao WangDan WangJianning WangPublished in: Oxidative medicine and cellular longevity (2018)
Prostate carcinoma causes a great number of deaths every year; therefore, there is an urgent need to find new drug candidates to treat advanced prostate cancer. Isobavachalcone (IBC) is the chalcone composition of Psoralea corylifolia Linn used in traditional Chinese medicine. Although IBC demonstrates potent anticancer efficacy in numerous types of human cancer cells, the cellular targets of IBC have not been fully defined. In our study, we found that IBC may induce reactive oxygen species- (ROS-) mediated apoptosis via interaction with a selenocysteine (Sec) containing the antioxidant enzyme thioredoxin reductase 1 (TrxR1), and induce lethal endoplasmic reticulum (ER) stress by inhibiting TrxR1 activity and increasing ROS levels in human prostate cancer PC-3 cells. Furthermore, we also observed that knocking down TrxR1 would sensitized cancer cells to IBC treatment. Our study provides evidence for the anticancer mechanism of IBC with TrxR1 as a potential target.
Keyphrases
- prostate cancer
- reactive oxygen species
- endothelial cells
- radical prostatectomy
- cell death
- dna damage
- endoplasmic reticulum
- induced pluripotent stem cells
- pluripotent stem cells
- signaling pathway
- oxidative stress
- cancer therapy
- risk assessment
- anti inflammatory
- electronic health record
- replacement therapy
- drug delivery