Supine rollover plays an important role in the prevention of pressure sores in long-term bedridden patients. It is of great significance to study the mechanism of human supine rollover movement and to design the rehabilitation rollover mechanism in line with man-machine cooperation. In human supine rollover movement, shoulder and hip are the key parts of force application. Based on anatomical theory, the motion trajectory information of shoulder and hip skeletal rehabilitation parts is collected by combining optical motion capture and rigid body modeling. Following a kinematics simulation analysis, the simulation curve was compared with the experimental curve track; the numerical difference was small. It is proved that the simulation model is correct, and it is also shown that the designed rehabilitation rollover mechanism can better reproduce the natural rolling motion state of the human body. It can meet the requirements of human-machine synergistic assisted lateral roll rehabilitation aids and provides a solution for pressure sore prevention.