Decreasing ELK3 expression improves Bone Morphogenetic Protein Receptor 2 signaling and pulmonary vascular cell function in PAH.
Md Khadem AliLan ZhaoVinicio A de Jesus PerezMark R NicollsEdda F SpiekerkoetterPublished in: bioRxiv : the preprint server for biology (2023)
ELK3 is upregulated in blood and pulmonary vascular cells of PAH patients and may play a significant role in PAH potentially through modulating BMPR2 signaling.
Keyphrases
- end stage renal disease
- pulmonary hypertension
- polycyclic aromatic hydrocarbons
- induced apoptosis
- ejection fraction
- chronic kidney disease
- newly diagnosed
- poor prognosis
- pulmonary arterial hypertension
- peritoneal dialysis
- signaling pathway
- prognostic factors
- patient reported outcomes
- endoplasmic reticulum stress
- patient reported